Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …

Because of their unusual chemical structure, bile salts (BS) play a fundamental role in
intestinal lipid digestion and transport. BS have a planar arrangement of hydrophobic and …

Background Epidemiological studies have shown Per-and polyfluoroalkyl substances
(PFAS) to be associated with diseases of dysregulated lipid and sterol homeostasis such as …

Breast cancer (BC) is the most common malignancy and the second cause of cancer-
specific death in women from high-income countries. Recently, gut microbiota dysbiosis …

Beneficial effects of probiotic, prebiotic and polyphenol-rich interventions on fasting lipid
profiles have been reported, with changes in the gut microbiota composition believed to play …

Bile acids (BA) are amphipathic steroid acids synthesized from cholesterol in the liver. They
act as detergents to expedite the digestion and absorption of dietary lipids and lipophilic …

Ursodeoxycholic acid (UDCA) is a secondary bile acid issued from the transformation of
(cheno) deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal …

Recently, the concept of the brain-gut-microbiota (BGM) axis disturbances in the
pathogenesis of Alzheimer's disease (AD) has been receiving growing attention. At the …

Background: The gut microbiome has been linked to the onset of cardiometabolic diseases,
in part facilitated through gut microbiota-dependent metabolites such as trimethylamine-N …

Bile acids are important hydroxylated steroids that are synthesized in the liver from
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …