Hyperuricemia (HUA) is one of the major threats to human health. In recent years, with the
gradual increase in the incidence rate of Hua, the prevention and treatment of HUA has …

In a new approach, we considered the special affinity between Ni and poly-histidine tags of
recombinant urate oxidase to utilize Ni-MOF for immobilizing the enzyme. In this study, a …

Introduction: Trehalose is a significant rare sugar known for its stable properties and ability
to protect biomolecules from environmental factors. Methods: In this study, we present a …

Abstract Hexakis (m-phenylene ethynylene)(m-PE) macrocycles, with aromatic backbones
and multiple hydrogen-bonding side chains, had a very high propensity to self-assemble via …

This paper investigates the impact of taurine as an additive on the structural and functional
stability of urate oxidase. First, the effect of the processing parameters for the stabilization of …

In this work, the effect of trehalose was investigated on the structural stability of the d-Lactate
dehydrogenase (DLDH) enzyme. Initially, response surface methodology (RSM) was …

Uricase is widely used to treat hyperuricemia and gout. Its clinical use is complicated by
patients severe allergy, hypersensitivity and anaphylactic reactions. Uricase from …

Solid-based residues (SBRs) of Cordyceps militaris are often considered as waste after the
cultivation of the fruiting body. To demonstrate the value of this by-product, different ratios of …

Thymidine phosphorylase (TYPH) is an enzyme involved in pyrimidine catabolism and its
mutation is associated with chemoresistance of colon cancer to 5-fluorouracil (5-FU) …

El ácido úrico está relacionado de forma directa e indirectamente con diversas
enfermedades, principalmente con la hiperuricemia. En la actualidad, existen métodos de …