In recent years, there has been an explosive increase in genetic studies related to autism
spectrum disorder (ASD). This implicated the accumulation of a large amount of molecular …

Hematopoietic development is governed by the coordinated expression of lineage-and
differentiation stage-specific genes. Transcription factors play major roles in this process and …

Background Given the rarity of most single-gene Mendelian disorders, concerted efforts of
data exchange between clinical and scientific communities are critical to optimize molecular …

The population history of Aboriginal Australians remains largely uncharacterized. Here we
generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama …

To explore the genetic architecture of human overgrowth syndromes and human growth
control, we performed experimental and bioinformatic analyses of 710 individuals with …

Yin and yang 1 (YY1) is a well-known zinc-finger transcription factor with crucial roles in
normal development and malignancy. YY1 acts both as a repressor and as an activator of …

Background Intellectual disability is a very complex condition where more than 600 genes
have been reported. Due to this extraordinary heterogeneity, a large proportion of patients …

Transcription factors operate in developmental processes to mediate inductive events and
cell competence, and perturbation of their function or regulation can dramatically affect …

Histones mediate dynamic packaging of nuclear DNA in chromatin, a process that is
precisely controlled to guarantee efficient compaction of the genome and proper …

Schizophrenia is a group of severe mental disorders. ZBTB20 is critical in brain
development and corticogenesis and its dysfunction induces various neural disorders …