The specialised antigen sampling M cells represent an efficient portal for mucosal drug and
vaccine delivery. Delivery may be achieved using synthetic particulate delivery vehicles …

Intestinal M cells, the specialised antigen-sampling cells of the mucosal immune system, are
exploited by Salmonella and other pathogens as a route of invasion. Salmonella entry into M …

Salmonella enterica subspecies I, serovar Typhimurium (S. typhimurium), is a leading cause
of human gastroenteritis, and is used as a mouse model of human typhoid fever. The …

Background Inserting transgenes into bacterial chromosomes is generally quite involved,
requiring a selection for cells carrying the insertion, usually for drug-resistance, or multiple …

Cell signalling through Frizzled receptors has evolved to considerable complexity within the
metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose …

Current paediatric immunization programmes include too many injections in the first months
of life. Oral or nasal vaccine delivery eliminates the requirement for needles and can induce …

Background: Helicobacter pylori remains a global health hazard, and vaccination would be
ideal for its control. Natural infection appears not to induce protective immunity. Thus, the …

The delivery of vaccines through the mucosal route is very practical, non-invasive and
efficacious for the induction of mucosal and systemic immune responses. Appropriately …

Note: This article is part of the Perspective Series" The Future of vaccine design", edited by
Peter Palese and Adolfo García-Sastre, published in issues 1–3 of volume 110. Due to a …

The development of new-generation vaccines has followed a number of strategic avenues
including the use of live recombinant bacteria. Of these, the use of genetically engineered …