The renin-angiotensin system is a central component of the physiological and pathological
responses of cardiovascular system. Its primary effector hormone, angiotensin II (ANG II), not …

The COVID-19 pandemic has spawned global health crisis of unprecedented magnitude,
claiming millions of lives and pushing healthcare systems in many countries to the brink …

Epidemiological, migration, intervention, and genetic studies in humans and animals
provide very strong evidence of a causal link between high salt intake and high blood …

Angiotensins are peptide hormones derived from the protein precursor angiotensinogen by
the sequential actions of proteolytic enzymes (Figure 1). The classic pathway of angiotensin …

Acute respiratory distress syndrome (ARDS) is an often fatal condition for which a genetic
predisposition is postulated, although no specific genes have been identified to date …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

The renin-angiotensin system plays a critical role in sodium and fluid homeostasis. Genetic
or acquired alterations in the expression of components of this system are strongly …

Essential hypertension has a genetic basis. Accumulating evidence, including findings of
elevation of arterial blood pressure in mice lacking the endothelial nitric oxide synthase …

Some 12 years ago, a polymorphism of the angiotensin I-converting enzyme (ACE) gene
became the first genetic element shown to impact substantially on human physical …

Hypertension is a common multifactorial vascular disorder of largely unknown cause.
Recognition that hypertension is in part genetically determined has motivated studies to …