Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …

Abstract miRNAs act as oncogenes or tumor suppressors in a wide variety of human
cancers, including prostate cancer (PCa). We found a severe and consistent downregulation …

MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate
gene expression, thereby affecting crucial processes in cancer development. miRNAs offer …

Background Osteosarcomas are the most common primary malignant tumors of bone and
show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of …

MicroRNAs, the non-coding single-stranded RNA of 19–25 nucleotides are emerging as
robust players of gene regulation. Plethora of evidences support that the ability of …

Osteosarcoma is the most common bone cancer in children and young adults. Surgery and
multi-agent chemotherapy are the standard treatment regimens for this disease. New …

Tunneling nanotubes (TnTs) represent a novel mechanism by which intercellular
components such as proteins, Golgi vesicles, and mitochondria can be transferred from cell …

Many RNAs are processed into biologically active transcripts, the aberrant expression of
which can contribute to disease phenotypes. For example, the primary microRNA-17-92 (pri …

Background Canine osteosarcoma is clinically nearly identical to the human disease, but is
common and highly heritable, making genetic dissection feasible. Results Through genome …