The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …

Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Human brain organoids replicate much of the cellular diversity and developmental anatomy
of the human brain. However, the physiology of neuronal circuits within organoids remains …

Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

The assembly of cortical circuits involves the generation and migration of interneurons from
the ventral to the dorsal forebrain,–, which has been challenging to study at inaccessible …

In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Brain organoids created from human pluripotent stem cells represent a promising approach
for brain repair. They acquire many structural features of the brain and raise the possibility of …

Realizing the full potential of organoids and assembloids to model neural development and
disease will require improved methods for long-term, minimally invasive recording of …

Research on human cerebellar development and disease has been hampered by the need
for a human cell-based system that recapitulates the human cerebellum's cellular diversity …

Neuronal ensembles, defined as groups of neurons displaying recurring patterns of
coordinated activity, represent an intermediate functional level between individual neurons …