Titanium (Ti) and its alloys have been widely used as orthopedic implants, because of their
favorable mechanical properties, corrosion resistance and biocompatibility. Despite their …

Successful materials design for bone-tissue engineering requires an understanding of the
composition and structure of native bone tissue, as well as appropriate selection of …

Bone regeneration is a highly synchronized process that requires multiple biochemical,
bioelectrical, mechanical, and other physiological cues. The restoration and delivery of …

Proper immune responses are critical for successful biomaterial implantation. Here, four
scales of honeycomb-like TiO2 structures were custom made on titanium (Ti) substrates to …

In the last few years, the progress made in the field of nanotechnology has allowed
researchers to develop and synthesize nanosized materials with unique physicochemical …

The development of new nanomaterials with high biomedical performance and low toxicity is
essential to obtain more efficient therapy and precise diagnostic tools and devices. Recently …

The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

Osteomyelitis, as a severe bone disease caused by bacterial infection, can result in lifelong
disability or fatal sepsis. Considering that the infection is stubborn and deep-sited in bone …

Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

The synovial tissues under rheumatoid arthritis conditions are usually infiltrated by
inflammatory cells, particularly M1 macrophages with aberrant redox homeostasis, which …