Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Proteins constitute the majority of nature's worker biomolecules. Designed for specific
functions, complex tertiary structures make proteins ideal candidates for analysing natural …

The merging of click chemistry with discrete photochemical processes has led to the creation
of a new class of click reactions, collectively known as photoclick chemistry. These light …

Chemical protein modification has emerged as an invaluable tool for the development of
modified proteins. The complementary use of both genetic and chemical methods has …

The modification of proteins with non‐protein entities is important for a wealth of
applications, and methods for chemically modifying proteins attract considerable attention …

Protein-based conjugates are valuable constructs for a variety of applications. Conjugation
of proteins to fluorophores is commonly used to study their cellular localization and the …

Chemical modification of enzymes and immobilization used to be considered as separate
ways to improve enzyme properties. This review shows how the coupled use of both tools …

With the advent of bioconjugation chemistry in the last two decades, highlighted by the
Nobel Prize 2022, the quest for possible novel applications has been greatly intensified …

5-Methylene pyrrolones (5MPs) are highly thiol-specific and tracelessly removable
bioconjugation tools. 5MPs are readily prepared from primary amines in one step. 5MPs …

In the last decade and a half, numerous bioorthogonal reactions have been developed with
a goal to study biological processes in their native environment, ie, in living cells and …