Curcumin-loaded nanoparticles: A novel therapeutic strategy in treatment of central nervous system disorders
Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa.
Curcumin is widely used as a dietary spice and a topical medication for the treatment of …
Curcumin is widely used as a dietary spice and a topical medication for the treatment of …
Multiple sclerosis: immunopathology and treatment update
N Dargahi, M Katsara, T Tselios, ME Androutsou… - Brain sciences, 2017 - mdpi.com
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …
Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders
To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based
nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed …
nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed …
Neuroinflammation: microglia and T cells get ready to tango
In recent years, many paradigms concerning central nervous system (CNS) immunology
have been challenged and shifted, including the discovery of CNS-draining lymphatic …
have been challenged and shifted, including the discovery of CNS-draining lymphatic …
Teriflunomide and its mechanism of action in multiple sclerosis
Abstract Treatment of multiple sclerosis (MS) is challenging: disease-modifying treatments
(DMTs) must both limit unwanted immune responses associated with disease initiation and …
(DMTs) must both limit unwanted immune responses associated with disease initiation and …
Physical exercise attenuates experimental autoimmune encephalomyelitis by inhibiting peripheral immune response and blood-brain barrier disruption
PS Souza, ED Gonçalves, GS Pedroso, HR Farias… - Molecular …, 2017 - Springer
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) caused by demyelination, immune cell infiltration, and axonal damage. Herein, we …
(CNS) caused by demyelination, immune cell infiltration, and axonal damage. Herein, we …
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
We have recently identified T cells as important mediators of ischemic brain damage, but the
contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)–positive …
contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)–positive …
Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis
A prominent clinical symptom in multiple sclerosis (MS), a progressive disorder of the central
nervous system (CNS) due to heightened neuro-inflammation, is learning and memory …
nervous system (CNS) due to heightened neuro-inflammation, is learning and memory …
Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation
JM Reynolds, GJ Martinez… - Proceedings of the …, 2012 - National Acad Sciences
Toll-like receptors (TLRs) are critical components of innate immunity and function as rapid
pathogen sensors. TLR4 is expressed on CD4+ T cells as well, the functional significance of …
pathogen sensors. TLR4 is expressed on CD4+ T cells as well, the functional significance of …
Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis
Z Wang, X Zhang, S Lu, C Zhang, Z Ma, R Su… - Nature cardiovascular …, 2023 - nature.com
Atherosclerotic plaques form in the inner layer of arteries triggering heart attacks and
strokes. Although T cells have been detected in atherosclerosis, tolerance dysfunction as a …
strokes. Although T cells have been detected in atherosclerosis, tolerance dysfunction as a …