Immune regulation by parasites is a global concept that includes suppression, diversion,
and conversion of the host immune response to the benefit of the pathogen. While many …

Abstract Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma
including induction of the IgE isotype switch, expression of vascular cell adhesion molecule …

The role of Th1/Th2 polarization in mucosal immunity | Nature Medicine Skip to main content
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Vitamin D receptor (VDR) polymorphisms have been associated with several immune-
related diseases, and VDR and vitamin D itself modulate T cell differentiation. VDR maps to …

Recent genetic and functional studies highlight the importance of IL-4/IL-13 signalling in the
development of asthma and atopy. Here, Taro Shirakawa and colleagues discuss genetic …

Hundreds of genetic association studies on asthma-related phenotypes have been
conducted in different populations. To date, variants in 64 genes have been reported to be …

The human signal transducer and activator of transcription 6 (STAT6) gene represents one
of the most promising candidate genes for asthma and other inflammatory diseases on the …

Asthma, one of the most common chronic diseases, is a complex and heterogeneous
disorder. The results of genome screens for asthma-related traits in 11 different populations …

BACKGROUND: Immune responses characterized by TH2 type cells and IgE are important
for the development of asthma and atopy. The transcription factors STAT6, GATA3, and …

Asthma and associated phenotypes are complex traits most probably caused by an
interaction of multiple disease susceptibility genes and environmental factors. Major …