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Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
It is not known exactly where amyloid-β (Aβ) fibrils begin to accumulate in individuals with
Alzheimer's disease (AD). Recently, we showed that abnormal levels of Aβ42 in …
Alzheimer's disease (AD). Recently, we showed that abnormal levels of Aβ42 in …
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles
Binding of programmed death ligand-1 (PD-L1) to programmed cell death protein-1 (PD1)
leads to cancer immune evasion via inhibition of T cell function. One of the defining …
leads to cancer immune evasion via inhibition of T cell function. One of the defining …
SCT: Spinal Cord Toolbox, an open-source software for processing spinal cord MRI data
For the past 25 years, the field of neuroimaging has witnessed the development of several
software packages for processing multi-parametric magnetic resonance imaging (mpMRI) to …
software packages for processing multi-parametric magnetic resonance imaging (mpMRI) to …
Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease
Human episodic memory critically depends on subregions of the medial temporal lobe,
which are part of functional brain systems such as the anterior-temporal and the posterior …
which are part of functional brain systems such as the anterior-temporal and the posterior …
SimpleITK image-analysis notebooks: a collaborative environment for education and reproducible research
Modern scientific endeavors increasingly require team collaborations to construct and
interpret complex computational workflows. This work describes an image-analysis …
interpret complex computational workflows. This work describes an image-analysis …
Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model
Classical migraine patients experience aura, which is transient neurological deficits
associated with cortical spreading depression (CSD), preceding headache attacks. It is not …
associated with cortical spreading depression (CSD), preceding headache attacks. It is not …
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …
Early stages of tau pathology and its associations with functional connectivity, atrophy and memory
In Alzheimer's disease, post-mortem studies have shown that the first cortical site where
neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial …
neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial …
Connectivity precedes function in the development of the visual word form area
What determines the cortical location at which a given functionally specific region will arise
in development? We tested the hypothesis that functionally specific regions develop in their …
in development? We tested the hypothesis that functionally specific regions develop in their …
DeepHarmony: A deep learning approach to contrast harmonization across scanner changes
Magnetic resonance imaging (MRI) is a flexible medical imaging modality that often lacks
reproducibility between protocols and scanners. It has been shown that even when care is …
reproducibility between protocols and scanners. It has been shown that even when care is …