The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections
Type-III interferons (IFN-λ, IFNL) are the most recently described family of IFNs. This family of
innate cytokines are increasingly being ascribed pivotal roles in host–pathogen interactions …
innate cytokines are increasingly being ascribed pivotal roles in host–pathogen interactions …
Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C
Background Since 2009, several studies have identified single-nucleotide polymorphisms
(SNPs) near the gene encoding for interleukin (IL)-28 (IL28B) that are strongly associated …
(SNPs) near the gene encoding for interleukin (IL)-28 (IL28B) that are strongly associated …
Host genetic variants in the pathogenesis of hepatitis C
M Rau, K Baur, A Geier - Viruses, 2012 - mdpi.com
Direct-acting antiviral drugs (DAAs) are currently replacing antiviral therapy for Hepatitis C
infection. Treatment related side effects are even worse and the emergence of resistant …
infection. Treatment related side effects are even worse and the emergence of resistant …
Dynamic changes in innate immune responses during direct‐acting antiviral therapy for HCV infection
JA Holmes, C Carlton‐Smith, AY Kim… - Journal of Viral …, 2019 - Wiley Online Library
The role of the endogenous interferon (IFN) system has been well characterized during IFN‐
based therapy for chronic hepatitis C virus (HCV) infection; less is known for direct‐acting …
based therapy for chronic hepatitis C virus (HCV) infection; less is known for direct‐acting …
A role of variance in interferon genes to disease severity in COVID-19 patients
L Gozman, K Perry, D Nikogosov, I Klabukov… - Frontiers in …, 2021 - frontiersin.org
The rapid rise and global consequences of the novel coronavirus disease 19 (COVID-19)
have again brought the focus of the scientific community on the possible host factors …
have again brought the focus of the scientific community on the possible host factors …
KPP: KEGG pathway painter
Background High-throughput technologies became common tools to decipher genome-wide
changes of gene expression (GE) patterns. Functional analysis of GE patterns is a daunting …
changes of gene expression (GE) patterns. Functional analysis of GE patterns is a daunting …
Genetic polymorphisms of the IFNλ genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China
AM Zhang, K Ma, Y Song, B Wang, Y Feng, L Liu… - Infection, Genetics and …, 2014 - Elsevier
Hepatitis C virus (HCV) is the pathogenic factor for hepatitis C disease, which could lead to
chronic or serious hepatic diseases. Previous studies have identified that the IL28B gene …
chronic or serious hepatic diseases. Previous studies have identified that the IL28B gene …
The impact of IL28B genotype and liver fibrosis on the hepatic expression of IP10, IFI27, ISG15, and MX1 and their association with treatment outcomes in patients …
K Domagalski, M Pawłowska, D Kozielewicz… - PLoS …, 2015 - journals.plos.org
The strong impact of interleukin 28B (IL28B) polymorphisms on sustained virological
response (SVR) after peginterferon and ribavirin treatment in patients with chronic hepatitis …
response (SVR) after peginterferon and ribavirin treatment in patients with chronic hepatitis …
Antiviral activity of the interferon α family: biological and pharmacological aspects of the treatment of chronic hepatitis C
C Scagnolari, G Antonelli - Expert Opinion on Biological Therapy, 2013 - Taylor & Francis
Introduction: Type I interferons (IFNs) comprise a group of at least 13 structurally related
subtypes of IFN-α with similar, but not identical, biological activities. Each subtype displays a …
subtypes of IFN-α with similar, but not identical, biological activities. Each subtype displays a …
Pretreatment predictors of response to PegIFN-RBV therapy in Egyptian patients with HCV genotype 4
Background Egypt has the highest prevalence of a difficult to treat chronic hepatitis C virus
(HCV), genotype 4. Pretreatment factors could guide individualization of therapy which aids …
(HCV), genotype 4. Pretreatment factors could guide individualization of therapy which aids …