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Lyophilization of small-molecule injectables: an industry perspective on formulation development, process optimization, scale-up challenges, and drug product quality …
A Butreddy, N Dudhipala, KY Janga, RP Gaddam - Aaps Pharmscitech, 2020 - Springer
Lyophilization is a pivotal manufacturing process to obtain a stable drug product that is
unstable as a ready-to-use formulation. Some formulations may require the addition of drug …
unstable as a ready-to-use formulation. Some formulations may require the addition of drug …
[HTML][HTML] HPMCAS-based amorphous solid dispersions in clinic: a review on manufacturing techniques (hot melt extrusion and spray drying), marketed products and …
Today, therapeutic candidates with low solubility have become increasingly common in
pharmaceutical research pipelines. Several techniques such as hot melt extrusion, spray …
pharmaceutical research pipelines. Several techniques such as hot melt extrusion, spray …
Polymer-assisted aripiprazole–adipic acid cocrystals produced by hot melt extrusion techniques
Pharmaceutical cocrystals offer a promising strategy to increase the solubility and
dissolution rate of poorly soluble drugs. However, their manufacturing process requires a …
dissolution rate of poorly soluble drugs. However, their manufacturing process requires a …
Formulating Ternary Inclusion Complex of Sorafenib Tosylate Using β-Cyclodextrin and Hydrophilic Polymers: Physicochemical Characterization and In Vitro …
Sorafenib tosylate (SFNT) is the first-line drug for hepatocellular carcinoma. It exhibits poor
solubility leading to low oral bioavailability subsequently requiring intake of large quantities …
solubility leading to low oral bioavailability subsequently requiring intake of large quantities …
[HTML][HTML] A comprehensive review on solid lipid nanoparticles as delivery vehicle for enhanced pharmacokinetic and pharmacodynamic activity of poorly soluble drugs
N Dudhipala - International Journal of Pharmaceutical Sciences …, 2019 - ijpsnonline.com
This article describes the current state and future perspectives of solid lipid nanoparticles for
achieving high delivery of drugs with greater therapeutic outcomes. The oral route is the …
achieving high delivery of drugs with greater therapeutic outcomes. The oral route is the …
Colloidal lipid nanodispersion enriched hydrogel of antifungal agent for management of fungal infections: comparative in-vitro, ex-vivo and in-vivo evaluation for oral …
N Dudhipala, AAA Youssef, N Banala - Chemistry and Physics of Lipids, 2020 - Elsevier
Ketoconazole (KZ) is broad spectrum antifungal drug, used for the treatment of fungal
infections. KZ's clinical topical use has been associated with some adverse effects in healthy …
infections. KZ's clinical topical use has been associated with some adverse effects in healthy …
The impact of process and formulation parameters on the fabrication of Efavirenz nanosuspension to improve drug solubility and dissolution
M Rashed, S Dadashzadeh… - Iranian Journal of …, 2022 - pmc.ncbi.nlm.nih.gov
Background Efavirenz nanosuspensions (EZ-NSs) were developed by the wet milling
method as the most promising top-down nanosizing technique. Different process and …
method as the most promising top-down nanosizing technique. Different process and …
Attenuation of lipid levels in triton induced hyperlipidemia rats through rosuvastatin calcium nanoparticles: Pharmacokinetic and pharmacodynamic studies
NR Dudhipala, SR Ettireddy… - Chemistry and Physics of …, 2021 - Elsevier
The aim of this research was to study the effect of marketed tablet (Crestor®) powder
suspension (MTPS) and nanoparticle formulation of rosuvastatin calcium (RC) on the …
suspension (MTPS) and nanoparticle formulation of rosuvastatin calcium (RC) on the …
Preparation, characterization and optimization of irbesartan loaded solid lipid nanoparticles for oral delivery
SS Kumara, R Alli - Asian Journal of Pharmacy and Technology, 2021 - indianjournals.com
The purpose of this study was to develop and evaluate irbesartan (IS) loaded solid lipid
nanoparticles (SLNs; IS-SLNs) that might enhance the oral bioavailability of IS. IS, an …
nanoparticles (SLNs; IS-SLNs) that might enhance the oral bioavailability of IS. IS, an …
[PDF][PDF] Muco-adhesive buccal tablets of candesartan cilexetil for oral delivery: preparation, in-vitro and ex-vivo evaluation
KS Samanthula, AG Bairi… - Journal of Drug Delivery …, 2021 - academia.edu
Candesartan cilexetil (CC) is an angiotensin II-receptor blocker (ARB). The antihypertensive
effect of CC 4-16 mg/day was as great as that of other once-daily dosage regimens …
effect of CC 4-16 mg/day was as great as that of other once-daily dosage regimens …