Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series

LR Brown, MS Sousa, MS Yule… - Journal of Cachexia …, 2024 - Wiley Online Library
Significant variation exists in the outcomes used in cancer cachexia trials, including
measures of body composition, which are often selected as primary or secondary endpoints …

Cancer cachexia: multilevel metabolic dysfunction

M Berriel Diaz, M Rohm, S Herzig - Nature Metabolism, 2024 - nature.com
Cancer cachexia is a complex metabolic disorder marked by unintentional body weight loss
or 'wasting'of body mass, driven by multiple aetiological factors operating at various levels. It …

Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression

GC Tobias, JLP Gomes, LG Fernandes, VA Voltarelli… - Scientific Reports, 2023 - nature.com
Exercise training reduces the incidence of several cancers, but the mechanisms underlying
these effects are not fully understood. Exercise training can affect the spleen function, which …

Imaging modalities for measuring body composition in patients with cancer: opportunities and challenges

UA Shah, TJ Ballinger, R Bhandari… - JNCI …, 2023 - academic.oup.com
Body composition assessment (ie, the measurement of muscle and adiposity) impacts
several cancer-related outcomes including treatment-related toxicities, treatment responses …

Defining and addressing research priorities in cancer cachexia through transdisciplinary collaboration

MA Park, CJ Whelan, S Ahmed, T Boeringer, J Brown… - Cancers, 2024 - mdpi.com
Simple Summary Cachexia occurs in up to 80% of patients with cancer. Although cancer-
associated cachexia dramatically decreases overall survival and quality of life, it is often …

Cancer cachexia: new insights and future directions

CR Mariean, OM Tiucă, A Mariean, OS Cotoi - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a major burden of disease worldwide, with cancer cachexia
being a poor prognosis factor which leads to a decreased quality of life and overall survival …

Age‐and sex‐specific changes in visceral fat mass throughout the life‐span

RB Baarts, MR Jensen, OM Hansen, B Haddock… - …, 2023 - Wiley Online Library
Objective Visceral fat mass (VFM) is a risk factor for cardiovascular diseases, type 2 diabetes
mellitus, and malignancy; however, normative data are limited. The aim of this study was to …

Detection of cancer‐associated cachexia in lung cancer patients using whole‐body [18F]FDG‐PET/CT imaging: A multi‐centre study

D Ferrara, EM Abenavoli, T Beyer… - Journal of Cachexia …, 2024 - Wiley Online Library
Background Cancer‐associated cachexia (CAC) is a metabolic syndrome contributing to
therapy resistance and mortality in lung cancer patients (LCP). CAC is typically defined …

Fat quantification: Imaging methods and clinical applications in cancer

SY Yan, YW Yang, XY Jiang, S Hu, YY Su… - European Journal of …, 2023 - Elsevier
Recently, the study of the relationship between lipid metabolism and cancer has evolved.
The characteristics of intratumoral and peritumoral fat are distinct and changeable during …

Leveraging real-world data to predict cancer cachexia stage, quality of life, and survival in a racially and ethnically diverse multi-institutional cohort of treatment-naïve …

JB Permuth, MA Park, DT Chen, T Basinski… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Introduction Cancer-associated cachexia (CC) is a progressive syndrome characterized by
unintentional weight loss, muscle atrophy, fatigue, and poor outcomes that affects most …