Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage loss
and accounts for a major source of pain and disability worldwide. However, effective …

The monitoring of tissue regeneration is particularly important. However, most materials do
not allow direct observation of the regeneration process in the cartilage layer. Here, using …

Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …

The field of osteoarthritis (OA) biology is rapidly evolving and brilliant progress has been
made this year as well. Landmark studies of OA biology published in 2021 and early 2022 …

Exosomes, remarkable extracellular vesicles, have emerged as an advanced frontier in
intercellular communication. This remarkable capacity positions them as promising …

Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury and accounts for
12% of all osteoarthritis. These injuries, often of the lower extremity joints, occur due to …

Aims Osteoarthritis (OA) is a common degenerative disease that is pathologically
characterized by destruction of the joint matrix and reduction of articular chondrocytes …

Critical-size bone defect repair is in high demand but is difficult to treat. Modern therapies,
such as autograft and cell-based treatments, face limitations, including potential …