An updated review on synthetic cathinones

J Soares, VM Costa, ML Bastos, F Carvalho… - Archives of …, 2021 - Springer
Cathinone, the main psychoactive compound found in the plant Catha edulis Forsk.(khat), is
a β-keto analogue of amphetamine, sharing not only the phenethylamine structure, but also …

Abuse potential and toxicity of the synthetic cathinones (ie,“Bath salts”)

AL Riley, KH Nelson, P To, R López-Arnau, P Xu… - Neuroscience & …, 2020 - Elsevier
The synthetic cathinones are derived from the naturally occurring drug cathinone found in
the khat plant (Catha edulis) and have chemical structures and neurochemical …

[HTML][HTML] Molecular and clinical aspects of potential neurotoxicity induced by new psychoactive stimulants and psychedelics

D Rudin, ME Liechti, D Luethi - Experimental neurology, 2021 - Elsevier
New psychoactive stimulants and psychedelics continue to play an important role on the
illicit new psychoactive substance (NPS) market. Designer stimulants and psychedelics both …

Psychoactive drugs—from chemical structure to oxidative stress related to dopaminergic neurotransmission. A review

G Jîtcă, BE Ősz, A Tero-Vescan, CE Vari - Antioxidants, 2021 - mdpi.com
Nowadays, more and more young people want to experience illegal, psychoactive
substances, without knowing the risks of exposure. Besides affecting social life …

Neurotoxicology of synthetic cathinone analogs

M Angoa-Pérez, JH Anneken, DM Kuhn - Neuropharmacology of New …, 2017 - Springer
The present review briefly explores the neurotoxic properties of methcathinone,
mephedrone, methylone, and methylenedioxypyrovalerone (MDPV), four synthetic …

3, 4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions

MJ Valente, AM Araújo, R Silva, ML Bastos… - Archives of …, 2016 - Springer
Synthetic cathinones have emerged in recreational drug markets as legal alternatives for
classical amphetamines. Though currently banned in several countries, 3, 4 …

Editor's Highlight: characterization of hepatotoxicity mechanisms triggered by designer cathinone drugs (β-Keto Amphetamines)

MJ Valente, AM Araújo, ML Bastos… - Toxicological …, 2016 - academic.oup.com
The use of cathinone designer drugs in recreational settings has been associated with
severe toxic effects, including liver damage. The precise mechanisms by which cathinones …

Structure-cytotoxicity relationship profile of 13 synthetic cathinones in differentiated human SH-SY5Y neuronal cells

J Soares, VM Costa, H Gaspar, S Santos… - Neurotoxicology, 2019 - Elsevier
Synthetic cathinones also known as β-keto amphetamines are a new group of recreational
designer drugs. We aimed to evaluate the cytotoxic potential of thirteen cathinones lacking …

Effects of mephedrone and amphetamine exposure during adolescence on spatial memory in adulthood: Behavioral and neurochemical analysis

P Grochecki, I Smaga, M Lopatynska-Mazurek… - International Journal of …, 2021 - mdpi.com
A synthetic cathinone, mephedrone is widely abused by adolescents and young adults.
Despite its widespread use, little is known regarding its long-term effects on cognitive …

[HTML][HTML] Binge-like mephedrone treatment induces memory impairment concomitant with brain kynurenic acid reduction in mice

M Marszalek-Grabska, I Zakrocka, B Budzynska… - Toxicology and Applied …, 2022 - Elsevier
Abstract While mephedrone (4-methylmethcathinone), a synthetic cathinone derivative, is
widely abused by adolescents and young adults, the knowledge about its long-term effects …