Recent advances in deep learning for protein-protein interaction analysis: A comprehensive review

M Lee - Molecules, 2023 - mdpi.com
Deep learning, a potent branch of artificial intelligence, is steadily leaving its transformative
imprint across multiple disciplines. Within computational biology, it is expediting progress in …

Genomics enters the deep learning era

E Routhier, J Mozziconacci - PeerJ, 2022 - peerj.com
The tremendous amount of biological sequence data available, combined with the recent
methodological breakthrough in deep learning in domains such as computer vision or …

Functional annotation of enzyme-encoding genes using deep learning with transformer layers

GB Kim, JY Kim, JA Lee, CJ Norsigian… - Nature …, 2023 - nature.com
Functional annotation of open reading frames in microbial genomes remains substantially
incomplete. Enzymes constitute the most prevalent functional gene class in microbial …

Deciphering the impact of genetic variation on human polyadenylation using APARENT2

J Linder, SE Koplik, A Kundaje, G Seelig - Genome biology, 2022 - Springer
Background 3′-end processing by cleavage and polyadenylation is an important and finely
tuned regulatory process during mRNA maturation. Numerous genetic variants are known to …

Interpreting cis-regulatory interactions from large-scale deep neural networks

S Toneyan, PK Koo - Nature Genetics, 2024 - nature.com
The rise of large-scale, sequence-based deep neural networks (DNNs) for predicting gene
expression has introduced challenges in their evaluation and interpretation. Current …

Interpretable perturbator for variable selection in near-infrared spectral analysis

C Duan, X Liu, W Cai, X Shao - Journal of Chemical Information …, 2023 - ACS Publications
A perturbator was developed for variable selection in near-infrared (NIR) spectral analysis
based on the perturbation strategy in deep learning for develo** interpretation methods. A …

Application of artificial intelligence tools in wastewater and waste gas treatment systems: Recent advances and prospects

SK Behera, S Karthika, B Mahanty, SK Meher… - Journal of …, 2024 - Elsevier
The non-linear complex relationships among the process variables in wastewater and waste
gas treatment systems possess a significant challenge for real-time systems modelling. Data …

Decoding biology with massively parallel reporter assays and machine learning

A La Fleur, Y Shi, G Seelig - Genes & Development, 2024 - genesdev.cshlp.org
Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of
sequence variation on gene expression. Reading out molecular phenotypes with …

Toward identification of functional sequences and variants in noncoding DNA

R Monti, U Ohler - Annual Review of Biomedical Data Science, 2023 - annualreviews.org
Understanding the noncoding part of the genome, which encodes gene regulation, is
necessary to identify genetic mechanisms of disease and translate findings from genome …

Varipred: Enhancing pathogenicity prediction of missense variants using protein language models

W Lin, J Wells, Z Wang, C Orengo, ACR Martin - bioRxiv, 2023 - biorxiv.org
Computational approaches for predicting the pathogenicity of genetic variants have
advanced in recent years. These methods enable researchers to determine the possible …