The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model
systems in biology since the 1970s, but only within the last two decades has this nematode …

Next-generation sequencing technology has enabled the detection of rare genetic or
somatic mutations and contributed to our understanding of disease progression and …

The genetic diversity of growing cellular populations, such as biofilms, solid tumours or
develo** embryos, is thought to be dominated by rare, exceptionally large mutant clones …

Genetic diversity is the fuel of evolution and facilitates adaptation to novel environments.
However, our understanding of what drives differences in the genetic diversity during the …

Motivation Next-generation deep sequencing of viral genomes, particularly on the Illumina
platform, is increasingly applied in HIV research. Yet, there is no standard protocol or …

Abstract Objectives Mitochondrial DNA (mtDNA)‐associated Leigh syndrome (LS) is
characterized by maternal inheritance, and the heteroplasmic mutant load of mtDNA …

Background and Purpose: Recent advances in molecular genetic testing have led to a rapid
increase in the understanding of the genetics of Leigh syndrome. Several studies have …

Abstract Background Mitochondrial DNA (mtDNA)-associated Leigh syndrome is influenced
by mutant pathogenicity and corresponding heteroplasmic loads; however, the manner in …

With growing interest in monitoring mutational processes in normal tissues, tumor
heterogeneity, and cancer evolution under therapy, the ability to accurately and …

Background The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich
repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells …