Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

In Alzheimer's disease, fibrillar tau pathology accumulates and spreads through the brain
and synapses are lost. Evidence from mouse models indicates that tau spreads trans …

Alzheimer's disease is a neurodegenerative disease that accounts for most of the 50-million
dementia cases worldwide in 2018. A large amount of evidence supports the amyloid …

Mitochondrial dysfunction is a fundamental pathological feature of Alzheimer's disease (AD).
However, toxicity and poor brain enrichment of existing mitophagy inducers limit their further …

Four fluid-based biomarkers have been developed into diagnostic tests for Alzheimer's
disease (AD) pathology: the ratio of 42 to 40 amino acid-long amyloid β, a marker of plaque …

Alzheimer's disease (AD) is a chronic neurodegenerative disease, with the characteristics of
neurofibrillary tangle (NFT) and senile plaque (SP) formation. Although great progresses …

Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …