Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total
body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of …

Despite its abundance in the environment, iron is poorly bioavailable and subject to strict
conservation and internal recycling by most organisms. In vertebrates, the stability of iron …

Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Background Thalassemia is an inherited hematological disorder categorized by a decrease
or absence of one or more of the globin chains synthesis. Beta‐thalassemia is caused by …

The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin
on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by …

Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the
most common monogenic diseases worldwide. Several clinical forms of α-thalassaemia and …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

Maintaining physiologic iron concentrations in tissues is critical for metabolism and host
defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes …