[HTML][HTML] Understanding human health through metatranscriptomics

T Ojala, E Kankuri, M Kankainen - Trends in Molecular Medicine, 2023 - cell.com
Metatranscriptomics has revolutionized our ability to explore and understand transcriptional
programs in microbial communities. Moreover, it has enabled us to gain deeper and more …

Contributions of the early-life microbiome to childhood atopy and asthma development

H Steininger, J Moltzau-Anderson, SV Lynch - Seminars in immunology, 2023 - Elsevier
The rapid rise in atopy and asthma in industrialized nations has led to the identification of
early life environmental factors that promote these conditions and spurred research into how …

Molecular accounting and profiling of human respiratory microbial communities: toward precision medicine by targeting the respiratory microbiome for disease …

AR Alsayed, A Abed, HA Khader… - International Journal of …, 2023 - mdpi.com
The wide diversity of microbiota at the genera and species levels across sites and
individuals is related to various causes and the observed differences between individuals …

Phage therapy for secondary bacterial infections with COVID-19

N Wu, LK Chen, T Zhu - Current opinion in virology, 2022 - Elsevier
With more than 200 million people affected and 4.5 million deaths so far, the coronavirus
disease 2019 (COVID-19) pandemic has become one of the greatest disasters in human …

Ventilator-associated pneumonia in critically ill patients with COVID-19 infection: a narrative review

S Boyd, S Nseir, A Rodriguez… - ERJ open …, 2022 - Eur Respiratory Soc
COVID pneumonitis can cause patients to become critically ill. They may require intensive
care and mechanical ventilation. Ventilator-associated pneumonia (VAP) is a concern. This …

Severe Dysbiosis and Specific Haemophilus and Neisseria Signatures as Hallmarks of the Oropharyngeal Microbiome in Critically Ill Coronavirus Disease 2019 …

J de Castilhos, E Zamir, T Hippchen… - Clinical infectious …, 2022 - academic.oup.com
Background At the entry site of respiratory virus infections, the oropharyngeal microbiome
has been proposed as a major hub integrating viral and host immune signals. Early studies …

Effect of invasive mechanical ventilation on the diversity of the pulmonary microbiota

C Liu, K Wu, T Sun, B Chen, Y Yi, R Ren, L **e, K **ao - Critical Care, 2022 - Springer
Pulmonary microbial diversity may be influenced by biotic or abiotic conditions (eg, disease,
smoking, invasive mechanical ventilation (MV), etc.). Specially, invasive MV may trigger …

Probiotics: A gut response to the COVID-19 pandemic but what does the evidence show?

S Brahma, A Naik, R Lordan - Clinical Nutrition ESPEN, 2022 - Elsevier
Since the global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), research has focused on understanding the etiology of coronavirus disease 2019 …

Differentiating infection, colonisation, and sterile inflammation in critical illness: the emerging role of host-response profiling

M Jeffrey, KJ Denny, J Lipman… - Intensive Care Medicine, 2023 - Springer
Infection results when a pathogen produces host tissue damage and elicits an immune
response. Critically ill patients experience immune activation secondary to both sterile and …

ICU-acquired colonization and infection related to multidrug-resistant bacteria in COVID-19 patients: a narrative review

A Gaudet, L Kreitmann, S Nseir - Antibiotics, 2023 - mdpi.com
A large proportion of ICU-acquired infections are related to multidrug-resistant bacteria
(MDR). Infections caused by these bacteria are associated with increased mortality, and …