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Engineering Pancreatic Islets to Transiently Codisplay on Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a Means of Mitigating Instant …
Most pancreatic islets are destroyed immediately after intraportal transplantation by an
instant blood-mediated inflammatory reaction (IBMIR) generated through activation of …
instant blood-mediated inflammatory reaction (IBMIR) generated through activation of …
Engineering pancreatic islets with a novel form of thrombomodulin protein to overcome early graft loss triggered by instant blood-mediated inflammatory reaction
The instant blood-mediated inflammatory reaction (IBMIR) is initiated by innate immune
responses that cause substantial islet loss after intraportal transplantation. Thrombomodulin …
responses that cause substantial islet loss after intraportal transplantation. Thrombomodulin …
[HTML][HTML] Protocol for transplanting pancreatic islets into the parametrial fat pad of female mice
Although the male epididymal fat pad is an effective site for islet transplantation, females
lack this tissue. Here, we present a protocol to assess the parametrial fat pad (PFP) adjacent …
lack this tissue. Here, we present a protocol to assess the parametrial fat pad (PFP) adjacent …
[HTML][HTML] Protocol for isolation and transplantation of rat pancreatic islets in the kidney capsule to treat diabetes
Islet transplantation offers promise for those with type 1 and late-stage type 2 diabetes;
however, islet isolation from the pancreas is challenging due to the interference of exocrine …
however, islet isolation from the pancreas is challenging due to the interference of exocrine …