Angiotensin receptor blocker, losartan ameliorates neuroinflammation and behavioral consequences of lipopolysaccharide injection
Aims Neuroinflammation has a critical role in brain diseases. Angiotensin II (Ang II) is an
important player in inflammation via stimulating of Ang II type 1 receptor (AT1R). In this …
important player in inflammation via stimulating of Ang II type 1 receptor (AT1R). In this …
Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy
JD Tchekalarova, NM Ivanova… - Pharmacology …, 2014 - Elsevier
Recently, we have shown that the blockade of AT 1 receptor might be useful as an adjuvant
treatment strategy for the prevention of oxidative stress and neurotoxicity caused by status …
treatment strategy for the prevention of oxidative stress and neurotoxicity caused by status …
Long-term treatment with losartan attenuates seizure activity and neuronal damage without affecting behavioral changes in a model of co-morbid hypertension and …
JD Tchekalarova, N Ivanova, D Atanasova… - Cellular and molecular …, 2016 - Springer
Over the last 10 years, accumulated experimental and clinical evidence has supported the
idea that AT 1 receptor subtype is involved in epilepsy. Recently, we have shown that the …
idea that AT 1 receptor subtype is involved in epilepsy. Recently, we have shown that the …
The potential therapeutic capacity of inhibiting the brain renin–angiotensin system in the treatment of co-morbid conditions in epilepsy
N Ivanova, J Tchekalarova - CNS drugs, 2019 - Springer
Epilepsy is one of the most prevalent neurological diseases and although numerous novel
anticonvulsants have been approved, the proportion of patients who are refractory to …
anticonvulsants have been approved, the proportion of patients who are refractory to …
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine …
J Tchekalarova, E Loyens, I Smolders - Epilepsy & Behavior, 2015 - Elsevier
In the management of epilepsy, AT 1 receptor antagonists have been suggested as an
additional treatment strategy. A hyperactive brain angiotensin (Ang) II system and …
additional treatment strategy. A hyperactive brain angiotensin (Ang) II system and …
Cerebral small vessel disease predisposes to temporal lobe epilepsy in spontaneously hypertensive rats
The link between cerebral small vessel disease (CSVD) and epilepsy has been poorly
investigated. Some reports suggest that CSVD may predispose to temporal lobe epilepsy …
investigated. Some reports suggest that CSVD may predispose to temporal lobe epilepsy …
Losartan suppresses the kainate-induced changes of angiotensin AT1 receptor expression in a model of comorbid hypertension and epilepsy
D Atanasova, J Tchekalarova, N Ivanova… - Life sciences, 2018 - Elsevier
Aims Experimental and clinical studies have demonstrated that components of renin-
angiotensin system are elevated in the hippocampus in epileptogenic conditions. In the …
angiotensin system are elevated in the hippocampus in epileptogenic conditions. In the …
Long-term intracerebroventricular infusion of angiotensin II after kainate-induced status epilepticus: Effects on epileptogenesis, brain damage, and diurnal behavioral …
NM Ivanova, D Atanasova, DM Pechlivanova… - Epilepsy & Behavior, 2015 - Elsevier
Our previous studies revealed that Angiotensin (Ang) II has anticonvulsant effects in acute
seizure models. However, data on its role in experimental models of epilepsy are missing. In …
seizure models. However, data on its role in experimental models of epilepsy are missing. In …
A review of clinically significant drug-drug interactions involving angiotensin II receptor antagonists and antiepileptic drugs
M Rusek, SJ Czuczwar - Expert Opinion on Drug Metabolism & …, 2020 - Taylor & Francis
Introduction Angiotensin II receptor blockers are widely used for the treatment of arterial
hypertension and heart failure. However, recent studies on animal models of seizures …
hypertension and heart failure. However, recent studies on animal models of seizures …
Effect of status epilepticus on expression of brain UDP‐glucuronosyltransferase 1a in rats
Y Asai, H Tanaka, M Nadai… - Biopharmaceutics & Drug …, 2018 - Wiley Online Library
Status epilepticus (SE) involves severe epileptic seizures that cause oxidative stress in the
brain. Oxidative stress is known to influence uridine 5'‐diposphate‐glucuronosyltransferase …
brain. Oxidative stress is known to influence uridine 5'‐diposphate‐glucuronosyltransferase …