Interlocking gene mutations, epigenetic alterations and microenvironmental features
perpetuate tumor development, growth, infiltration and spread. Consequently, intrinsic and …

Prostate cancer is the most frequently diagnosed malignancy in American men, and a more
aggressive form of the disease is particularly prevalent among African Americans. The …

Cellular senescence is a driver of many age-related pathologies. There is an active search
for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by …

The two most common primary bone malignancies, osteosarcoma (OS), and Ewing sarcoma
(ES), are both aggressive, highly metastatic cancers that most often strike teens, though both …

Ovarian clear-cell cancer is a rare subtype of epithelial ovarian cancer with unique clinical
and biological features. Despite optimal cytoreductive surgery and platinum-based …

Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer.
In early stages of disease the protein functions predominantly as a tumor suppressor …

Caveolins are a family of membrane proteins required for the formation of small plasma
membrane invaginations called caveolae that are implicated in cellular trafficking processes …

Pancreatic cancer remains one of the most lethal cancers due to late diagnosis and high
chemoresistance. Despite recent progression in the development of chemotherapies …

Caveolin-1 (Cav-1) is both a tumor suppressor and an oncoprotein. Cav-1 overexpression
was frequently confirmed in advanced cancer stages and positively associated with ABC …

CD99 is a cell surface molecule that has emerged as a novel target for Ewing sarcoma
(EWS), an aggressive pediatric bone cancer. This report provides the first evidence of …