The retina is an immune privileged tissue, which is protected from external and internal
insults by its blood-retina barriers and immune suppressive microenvironment. Apart from …

The term uveitis encompasses a very diverse group of inflammatory ocular diseases that
cause a significant burden of legal and economic blindness. Indeed, the socioeconomic …

The eye is a privileged site that cannot tolerate destructive inflammatory responses.
Inflammatory cells entering the anterior chamber of the eye in response to viral infection …

Experimental autoimmune uveitis (EAU) represents autoimmune uveitis in humans. We
examined the role of the interleukin (IL)-23–IL-17 and IL-12–T helper cell (Th) 1 pathways in …

Uveitis (intraocular inflammation) is a potentially blinding group of, probably autoimmune,
conditions predominantly occurring in the working age group. Although the aetiology is …

The model of experimental autoimmune uveitis (EAU) in mice and in rats is described. EAU
targets immunologically privileged retinal antigens and serves as a model of autoimmune …

Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal
cell wall peptidoglycan polysaccharide (SCW), which mimics human rheumatoid arthritis …

The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the
systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve …

We have recently found that susceptibility to streptococcal cell wall (SCW)-induced arthritis
in Lewis (LEW/N) rats is due, in part, to defective inflammatory and stress mediator-induced …

The pleiotropic cytokine tumour necrosis factor-alpha (TNF-α) is released from cells that
include macrophages and T-cells during inflammatory responses, orchestrating the initiation …