Metabolomics: beyond biomarkers and towards mechanisms
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …
Metabolomics for investigating physiological and pathophysiological processes
DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …
Emerging applications of metabolomics in drug discovery and precision medicine
DS Wishart - Nature reviews Drug discovery, 2016 - nature.com
Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective
Flavonoids are plant‐derived dietary components with a substantial impact on human
health. Research has expanded massively since it began in the 1930s, and the complex …
health. Research has expanded massively since it began in the 1930s, and the complex …
Review of recent developments in GC–MS approaches to metabolomics-based research
Background Metabolomics aims to identify the changes in endogenous metabolites of
biological systems in response to intrinsic and extrinsic factors. This is accomplished …
biological systems in response to intrinsic and extrinsic factors. This is accomplished …
Intestinal Microbiota in Cardiovascular Health and Disease: JACC State-of-the-Art Review
Despite major strides in reducing cardiovascular disease (CVD) burden with modification of
classic CVD risk factors, significant residual risks remain. Recent discoveries that linked …
classic CVD risk factors, significant residual risks remain. Recent discoveries that linked …
Gut microbiota metabolites and risk of major adverse cardiovascular disease events and death: a systematic review and meta‐analysis of prospective studies
Background Gut microbial metabolites have been implicated as novel risk factors for
cardiovascular events and premature death. The strength and consistency of associations …
cardiovascular events and premature death. The strength and consistency of associations …
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
There is substantial interest in the role of plant secondary metabolites as protective dietary
agents. In particular, the involvement of flavonoids and related compounds has become a …
agents. In particular, the involvement of flavonoids and related compounds has become a …
FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial
K McIntosh, DE Reed, T Schneider, F Dang… - Gut, 2017 - gut.bmj.com
Objective To gain mechanistic insights, we compared effects of low fermentable
oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high …
oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high …
[HTML][HTML] The role of protein in weight loss and maintenance
Over the past 20 y, higher-protein diets have been touted as a successful strategy to prevent
or treat obesity through improvements in body weight management. These improvements …
or treat obesity through improvements in body weight management. These improvements …