Sulfhydryl groups as targets of mercury toxicity
The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol;-
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …
Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury
Essential metals are crucial for the maintenance of cell homeostasis. Among the 23
elements that have known physiological functions in humans, 12 are metals, including iron …
elements that have known physiological functions in humans, 12 are metals, including iron …
Exploration of the medical periodic table: towards new targets
NPE Barry, PJ Sadler - Chemical Communications, 2013 - pubs.rsc.org
Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …
the metal, its oxidation state, the types and number of coordinated ligands and the …
Redox signaling mediated by thioredoxin and glutathione systems in the central nervous system
Abstract Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …
[HTML][HTML] Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis
Q Chi, Q Zhang, Y Lu, Y Zhang, S Xu, S Li - Redox biology, 2021 - Elsevier
Selenium (Se) deficiency and poor plasma Se levels can cause cardiovascular diseases by
decreasing selenoprotein levels. Neutrophil extracellular traps (NETs) may be the vicious …
decreasing selenoprotein levels. Neutrophil extracellular traps (NETs) may be the vicious …
Biosynthesis of Selenium Nanoparticles (via Bacillus subtilis BSN313), and Their Isolation, Characterization, and Bioactivities
Among the trace elements, selenium (Se) has great demand as a health supplement.
Compared to its other forms, selenium nanoparticles have minor toxicity, superior reactivity …
Compared to its other forms, selenium nanoparticles have minor toxicity, superior reactivity …
Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity
HA Spiller - Clinical toxicology, 2018 - Taylor & Francis
Introduction: There is increasing evidence that the pathophysiological target of mercury is in
fact selenium, rather than the covalent binding of mercury to sulfur in the body's ubiquitous …
fact selenium, rather than the covalent binding of mercury to sulfur in the body's ubiquitous …
Biomarkers of mercury toxicity: Past, present, and future trends
Mercury (Hg) toxicity continues to represent a global health concern. Given that human
populations are mostly exposed to low chronic levels of mercurial compounds …
populations are mostly exposed to low chronic levels of mercurial compounds …
Thioredoxin reductase as a pharmacological target
Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …
Heavy metals: toxicity and human health effects
Heavy metals are naturally occurring components of the Earth's crust and persistent
environmental pollutants. Human exposure to heavy metals occurs via various pathways …
environmental pollutants. Human exposure to heavy metals occurs via various pathways …