[HTML][HTML] Toll-like receptor 4 (TLR4) signaling in the trigeminal ganglion mediates facial mechanical and thermal hyperalgesia in rats
EI Araya, AR Barroso, J de Melo Turnes… - Physiology & …, 2020 - Elsevier
There is increasing evidence that the toll-like receptor 4 (TLR4) signaling pathway contribute
to development of hyperalgesia in the trigeminal system. The aim of the present study was to …
to development of hyperalgesia in the trigeminal system. The aim of the present study was to …
ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia
X Zheng, Y Tai, D He, B Liu, C Wang, X Shao… - Molecular …, 2019 - journals.sagepub.com
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that has been widely known as
a pain mediator involved in various pain states. Evidence indicates that ET-1 sensitizes …
a pain mediator involved in various pain states. Evidence indicates that ET-1 sensitizes …
Chemokine receptor CXCR2 in primary sensory neurons of trigeminal ganglion mediates orofacial itch
DJ Li, ZJ Zhong, XL Wang, N Wei, SJ Zhao… - Frontiers in Molecular …, 2023 - frontiersin.org
The CXCR2 chemokine receptor is known to have a significant impact on the initiation and
control of inflammatory processes. However, its specific involvement in the sensation of itch …
control of inflammatory processes. However, its specific involvement in the sensation of itch …
Role of endothelin in the pathophysiology of migraine: A new view on an old player
There is cumulating evidence that endothelin-1 (ET-1) may play a role in migraine, however
controversial findings still impede a conclusion to be drawn. Herein we tested the hypothesis …
controversial findings still impede a conclusion to be drawn. Herein we tested the hypothesis …