The lifecycle of skeletal muscle mitochondria in obesity
Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …
[HTML][HTML] Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle
Exercise training enhances physical performance and confers health benefits, largely
through adaptations in skeletal muscle. Mitochondrial adaptation, encompassing …
through adaptations in skeletal muscle. Mitochondrial adaptation, encompassing …
Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
Mitochondrial health is critical for skeletal muscle function and is improved by exercise
training through both mitochondrial biogenesis and removal of damaged/dysfunctional …
training through both mitochondrial biogenesis and removal of damaged/dysfunctional …
Targeting long non-coding RNA to therapeutically upregulate gene expression
C Wahlestedt - Nature reviews Drug discovery, 2013 - nature.com
The majority of currently available drugs and tool compounds exhibit an inhibitory
mechanism of action and there is a relative lack of pharmaceutical agents that are capable …
mechanism of action and there is a relative lack of pharmaceutical agents that are capable …
Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation
The ability to specifically upregulate genes in vivo holds great therapeutic promise. Here we
show that inhibition or degradation of natural antisense transcripts (NATs) by single …
show that inhibition or degradation of natural antisense transcripts (NATs) by single …
The long non-coding RNAs in neurodegenerative diseases: novel mechanisms of pathogenesis
Background: Long-non-coding RNAs (lncRNAs), RNA molecules longer than 200
nucleotides, have been involved in several biological processes and in a growing number of …
nucleotides, have been involved in several biological processes and in a growing number of …
Evolving and expanding the roles of mitophagy as a homeostatic and pathogenic process
ÅB Gustafsson, GW Dorn - Physiological reviews, 2019 - journals.physiology.org
The central functions fulfilled by mitochondria as both energy generators essential for tissue
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …
Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases
P Wu, X Zuo, H Deng, X Liu, L Liu, A Ji - Brain research bulletin, 2013 - Elsevier
Long noncoding RNAs (lncRNAs) have been attracting immense research interest, while
only a handful of lncRNAs have been characterized thoroughly. Their involvement in the …
only a handful of lncRNAs have been characterized thoroughly. Their involvement in the …
Parkinson's disease
Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder
characterized by a profound and selective loss of nigrostriatal dopaminergic neurons …
characterized by a profound and selective loss of nigrostriatal dopaminergic neurons …
High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression
MicroRNAs (miRNA), small noncoding RNA molecules, may regulate protein synthesis,
while resistance exercise training (RT) is an efficient strategy for stimulating muscle protein …
while resistance exercise training (RT) is an efficient strategy for stimulating muscle protein …