The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Improving the solubility and permeability of drugs via cocrystallization is an important theme
in crystal engineering with practical applications for the discovery and development of high …

Recently, pharmaceutical cocrystals have gained immense interest because of their
potential to tune mechanical, pharmacokinetic, and physicochemical properties of active …

Bilosomes are innovative vesicular carriers containing bile salt with a non-ionic surfactant.
Being highly flexible, bilosomes can squeeze themselves through the skin carrying the drug …

For the purpose of enhancing the solubility and humidity stability of pymetrozine (PMZ), a
highly active but nonbiocidal pesticide, new multicomponent crystals were developed based …

A supramolecular nanoprodrug (DOX@ GP5⊃ Pro-NFA) was constructed based on the host–
guest complexation of chloride channel blocker prodrug (Pro-NFA) and glycosylated pillar …

Abacavir (ABC) is a carbocyclic 2′-deoxyguanosine nucleoside reverse transcriptase
inhibitor specifically prescribed for the treatment of HIV infection. However, as a BCS class III …

Co-crystal innovation is an opportunity in drug development for both scientists and industry.
In line with the “green pharmacy” concept for obtaining safer methods and advanced …

Poor solubility and dissolution property of pharmaceuticals largely limits their bioavailability
and efficacy, and development of a multicomponent crystal is one of the effective …

Trimethoprim (TMP) is an active pharmaceutical ingredient with poor aqueous solubility.
Here, we describe the cocrystallization of TMP with five co-formers, three bipyridines and …