Interfacing coacervates with membranes: from artificial organelles and hybrid protocells to intracellular delivery

T Lu, S Javed, C Bonfio, E Spruijt - Small Methods, 2023 - Wiley Online Library
Compartmentalization is crucial for the functioning of cells. Membranes enclose and protect
the cell, regulate the transport of molecules entering and exiting the cell, and organize …

Phase-separated droplets swim to their dissolution

E Jambon-Puillet, A Testa, C Lorenz, RW Style… - Nature …, 2024 - nature.com
Biological macromolecules can condense into liquid domains. In cells, these condensates
form membraneless organelles that can organize chemical reactions. However, little is …

Microplastics destabilize lipid membranes by mechanical stretching

JB Fleury, VA Baulin - Proceedings of the National Academy of Sciences, 2021 - pnas.org
Estimated millions of tons of plastic are dumped annually into oceans. Plastic has been
produced only for 70 y, but the exponential rise of mass production leads to its widespread …

More than just a barrier: using physical models to couple membrane shape to cell function

F Frey, T Idema - Soft matter, 2021 - pubs.rsc.org
The correct execution of many cellular processes, such as division and motility, requires the
cell to adopt a specific shape. Physically, these shapes are determined by the interplay of …

A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces

RK Sadhu, SR Barger, S Penič, A Iglič, M Krendel… - Soft Matter, 2023 - pubs.rsc.org
Phagocytosis is the process of engulfment and internalization of comparatively large
particles by cells, and plays a central role in the functioning of our immune system. We study …

Nonadditivity in many-body interactions between membrane-deforming spheres increases disorder

A Azadbakht, TR Weikl, DJ Kraft - ACS nano, 2024 - ACS Publications
Membrane-induced interactions play an important role in organizing membrane proteins.
Measurements of the interactions between two and three membrane deforming objects have …

Dynamic shapes of floppy vesicles enclosing active Brownian particles with membrane adhesion

P Iyer, G Gompper, DA Fedosov - Soft matter, 2023 - pubs.rsc.org
Recent advances in micro-and nano-technologies allow the construction of complex active
systems from biological and synthetic materials. An interesting example is active vesicles …

Autonomous engulfment of active colloids by giant lipid vesicles

F Fessler, M Wittmann, J Simmchen, A Stocco - Soft Matter, 2024 - pubs.rsc.org
Our ability to design artificial micro/nanomachines able to perform sophisticated tasks
crucially depends on our understanding of their interaction with biosystems and their …

Origin of metal cluster tuning enzyme activity at the bio-nano interface

Y Cao, Y Qiao, S Cui, J Ge - JACS Au, 2022 - ACS Publications
Detailed understanding of how the bio-nano interface orchestrates the function of both
biological components and nanomaterials remains ambiguous. Here, through a combination …

Wrap** pathways of anisotropic dumbbell particles by giant unilamellar vesicles

A Azadbakht, B Meadowcroft, T Varkevisser… - Nano Letters, 2023 - ACS Publications
Endocytosis is a key cellular process involved in the uptake of nutrients, pathogens, or the
therapy of diseases. Most studies have focused on spherical objects, whereas biologically …