Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

While metal ions such as copper and zinc are essential in biology, they are also linked to
several amyloid-related diseases, including Alzheimer's disease (AD). Zinc and copper can …

Oxidative stress is linked to the etiology of Alzheimer's disease (AD), the most common
cause of dementia in the elderly. Redox active metal ions such as copper catalyze the …

The labile metal pool involved in intracellular trafficking and homeostasis is the portion
susceptible to environmental stress. Herein, we visualized the different intracellular …

C-Terminally modified peptides are important for the development and delivery of peptide-
based pharmaceuticals because they impact peptide activity, stability, hydrophobicity, and …

In the context of Alzheimer's disease (AD), the production of HO˙ by copper–amyloid beta
(Aβ) in the presence of ascorbate is known to be deleterious for the Aβ peptide itself and …

Oxidative stress and the formation of plaques which contain amyloid-β (Aβ) peptides are two
key hallmarks of Alzheimer's disease (AD). Dityrosine is found in the plaques of AD patients …

Copper is an essential element to play significant roles in human health associated to the
strong redox properties of Cu (I) and Cu (II). The concurrent monitoring of copper species in …

Along with aggregation of the amyloid-β (Aβ) peptide and subsequent deposit of amyloid
plaques, oxidative stress is an important feature in Alzheimer's disease. Cu bound to Aβ is …

Tau protein aggregation and its hyperphosphorylation play an important role in the
pathogenesis of Alzheimer's disease. There is also considerable evidence for the …