Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

It has long been recognized that energy metabolism is linked to the production of reactive
oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by …

Background: Aldehydes are highly reactive molecules. While several non-P450 enzyme
systems participate in their metabolism, one of the most important is the aldehyde …

Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in
experimental animal models have indicated the central role of mitochondria both in lifespan …

Two-dimensional gel electrophoresis has been instrumental in the birth and developments
of proteomics, although it is no longer the exclusive separation tool used in the field of …

Aged mammalian tissues show a decreased capacity to produce ATP by oxidative
phosphorylation due to dysfunctional mitochondria. The mitochondrial content of rat brain …

Significance: Fatigue is one of the most common symptoms of cancer and its treatment,
manifested in the clinic through weakness and exercise intolerance. These side effects not …