Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

Small interfering RNAs (siRNAs) technology has emerged as a promising potential
treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential …

Small interfering RNAs offer novel opportunities to inhibit gene expression in a highly
selective and efficient manner but depend on cytosolic translocation with synthetic delivery …

Polyethylenimines (PEIs) have proven to be highly efficient and versatile agents for nucleic
acid delivery in vitro and in vivo. Despite the low biodegradability of these polymers, they …

In this study, we designed and synthesized a biodegradable dendronized polypeptide
(denpol) platform for delivery of small interfering RNA (siRNA). The novel denpol …

Cancer is one of the leading non-communicable diseases with highest mortality rates
worldwide. About half of all cancer patients receive radiation treatment in the course of their …

Nine sequence-defined, polycationic oligomers were synthesized containing motifs of three
consecutive tyrosines (Y3) as stabilizing components for pDNA and siRNA polyplex …

Messenger RNA (mRNA) therapeutics have recently demonstrated high clinical potential
with the accelerated approval of SARS-CoV-2 vaccines. To fulfill the promise of …

Efficiency of polyethylenimine (PEI) for nucleic acid delivery is affected by the size of the
carrier and length of the nucleic acids. For instance, PEIs with molecular weights between …

Purpose Short linear peptides have a high potential for delivering various drugs with
therapeutic potential, including nucleic acids. Recently, we have shown that the cationic …