Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

T Barichello, JS Generoso, M Singer, F Dal-Pizzol - Critical care, 2022 - Springer
A biomarker describes a measurable indicator of a patient's clinical condition that can be
measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis …

Gut-lung crosstalk in sepsis-induced acute lung injury

X Zhou, Y Liao - Frontiers in microbiology, 2021 - frontiersin.org
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common acute
and severe cases of the respiratory system with complicated pathogenesis and high …

Bacillus siamensis Targeted Screening from Highly Colitis-Resistant Pigs Can Alleviate Ulcerative Colitis in Mice

X Fang, H Liu, Y Du, L Jiang, F Gao, Z Wang, Z Chi… - Research, 2024 - spj.science.org
Ulcerative colitis (UC) is often accompanied by intestinal inflammation and disruption of
intestinal epithelial structures, which are closely associated with changes in the intestinal …

Pathophysiology of sepsis

P Arina, M Singer - Current Opinion in Anesthesiology, 2021 - journals.lww.com
Sepsis represents a dysregulated host response to infection leading to organ dysfunction.
Here, the pathogen triggers an initial exaggerated inflammatory-immune response that …

Lipocalin 2—not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials

S Asaf, F Maqsood, J Jalil, Z Sarfraz, A Sarfraz… - Immunologic …, 2023 - Springer
Abstract Lipocalin 2 (Lcn2), also known as neutrophil gelatinase–associated lipocalin, is an
innate immune protein encoded by the LCN2 gene. In this study, we investigated various …

Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury in mice

B **e, M Wang, X Zhang, Y Zhang, H Qi, H Liu… - Nature …, 2024 - nature.com
Sepsis is a critical global health concern linked to high mortality rates, often due to acute
lung injury (ALI)/acute respiratory distress syndrome (ARDS). While the gut-lung axis …

DAMPs and radiation injury

S Yamaga, M Aziz, A Murao, M Brenner… - Frontiers in …, 2024 - frontiersin.org
The heightened risk of ionizing radiation exposure, stemming from radiation accidents and
potential acts of terrorism, has spurred growing interests in devising effective …

Circular RNA CircHIPK3 promotes homeostasis of the intestinal epithelium by reducing MicroRNA 29b function

L **ao, XX Ma, J Luo, HK Chung, MS Kwon, TX Yu… - Gastroenterology, 2021 - Elsevier
Background & Aims Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs
that form covalently closed circles. Although circRNAs influence many biological processes …

Changes in gut microbiota in the acute phase after spinal cord injury correlate with severity of the lesion

G Bazzocchi, S Turroni, MC Bulzamini, F D'Amico… - Scientific reports, 2021 - nature.com
After spinal cord injury (SCI), patients face many physical and psychological issues
including intestinal dysfunction and comorbidities, strongly affecting quality of life. The gut …

Intestinal microbiota-an unmissable bridge to severe acute pancreatitis-associated acute lung injury

Z Wang, F Li, J Liu, Y Luo, H Guo, Q Yang… - Frontiers in …, 2022 - frontiersin.org
Severe acute pancreatitis (SAP), one of the most serious abdominal emergencies in general
surgery, is characterized by acute and rapid onset as well as high mortality, which often …