Lessons learned from approval of aducanumab for Alzheimer's disease

JL Heidebrink, HL Paulson - Annual review of medicine, 2024 - annualreviews.org
When the US Food and Drug Administration used the accelerated approval process to
authorize the use of the antiamyloid drug aducanumab to treat Alzheimer's disease (AD) …

Sex and gender differences in neurodegenerative diseases: challenges for therapeutic opportunities

A Bianco, Y Antonacci, M Liguori - International journal of molecular …, 2023 - mdpi.com
The term “neurodegenerative diseases”(NDs) identifies a group of heterogeneous diseases
characterized by progressive loss of selectively vulnerable populations of neurons, which …

Roles of Cytokines in Alzheimer's Disease

Z Chen, YL Balachandran, WP Chong… - International Journal of …, 2024 - mdpi.com
The neuroimmune system is a collection of immune cells, cytokines, and the glymphatic
system that plays a pivotal role in the pathogenesis and progression of Alzheimer's disease …

[HTML][HTML] The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction

WY Fu, NY Ip - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive
deterioration of cognitive functions. Due to the extended global life expectancy, the …

Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population

E Simmonds, G Leonenko, U Yaman, E Bellou… - Translational …, 2024 - nature.com
Although there are several genome-wide association studies available which highlight
genetic variants associated with Alzheimer's disease (AD), often the X chromosome is …

Receptor–ligand interaction controls microglial chemotaxis and amelioration of Alzheimer's disease pathology

SF Lau, AKY Fu, NY Ip - Journal of Neurochemistry, 2023 - Wiley Online Library
Microglia maintain brain homeostasis through their ability to survey and phagocytose
danger‐associated molecular patterns (DAMPs). In Alzheimer's disease (AD), microglial …

Sexual dimorphism in neurodegenerative diseases and in brain ischemia

T Zalewska, P Pawelec, K Ziabska, M Ziemka-Nalecz - Biomolecules, 2022 - mdpi.com
Epidemiological studies and clinical observations show evidence of sexual dimorphism in
brain responses to several neurological conditions. It is suggested that sex-related …

Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects

Ö İş, Y Min, X Wang, SR Oatman, A Abraham Daniel… - Glia, 2025 - Wiley Online Library
Alzheimer's disease (AD) is the most common neurodegenerative dementia with multi‐
layered complexity in its molecular etiology. Multiple omics‐based approaches, such as …

[HTML][HTML] Minding the gap: exploring neuroinflammatory and microglial sex differences in Alzheimer's disease

EG Reed, PR Keller-Norrell - International Journal of Molecular Sciences, 2023 - mdpi.com
Research into Alzheimer's Disease (AD) describes a link between AD and the resident
immune cells of the brain, the microglia. Further, this suspected link is thought to have …

A blood‐based multi‐pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups

Y Jiang, H Uhm, FC Ip, L Ouyang, RMN Lo… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Existing blood‐based biomarkers for Alzheimer's disease (AD) mainly
focus on its pathological features. However, studies on blood‐based biomarkers associated …