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Lessons learned from approval of aducanumab for Alzheimer's disease
JL Heidebrink, HL Paulson - Annual review of medicine, 2024 - annualreviews.org
When the US Food and Drug Administration used the accelerated approval process to
authorize the use of the antiamyloid drug aducanumab to treat Alzheimer's disease (AD) …
authorize the use of the antiamyloid drug aducanumab to treat Alzheimer's disease (AD) …
Sex and gender differences in neurodegenerative diseases: challenges for therapeutic opportunities
The term “neurodegenerative diseases”(NDs) identifies a group of heterogeneous diseases
characterized by progressive loss of selectively vulnerable populations of neurons, which …
characterized by progressive loss of selectively vulnerable populations of neurons, which …
Roles of Cytokines in Alzheimer's Disease
Z Chen, YL Balachandran, WP Chong… - International Journal of …, 2024 - mdpi.com
The neuroimmune system is a collection of immune cells, cytokines, and the glymphatic
system that plays a pivotal role in the pathogenesis and progression of Alzheimer's disease …
system that plays a pivotal role in the pathogenesis and progression of Alzheimer's disease …
[HTML][HTML] The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction
WY Fu, NY Ip - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive
deterioration of cognitive functions. Due to the extended global life expectancy, the …
deterioration of cognitive functions. Due to the extended global life expectancy, the …
Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population
E Simmonds, G Leonenko, U Yaman, E Bellou… - Translational …, 2024 - nature.com
Although there are several genome-wide association studies available which highlight
genetic variants associated with Alzheimer's disease (AD), often the X chromosome is …
genetic variants associated with Alzheimer's disease (AD), often the X chromosome is …
Receptor–ligand interaction controls microglial chemotaxis and amelioration of Alzheimer's disease pathology
Microglia maintain brain homeostasis through their ability to survey and phagocytose
danger‐associated molecular patterns (DAMPs). In Alzheimer's disease (AD), microglial …
danger‐associated molecular patterns (DAMPs). In Alzheimer's disease (AD), microglial …
Sexual dimorphism in neurodegenerative diseases and in brain ischemia
T Zalewska, P Pawelec, K Ziabska, M Ziemka-Nalecz - Biomolecules, 2022 - mdpi.com
Epidemiological studies and clinical observations show evidence of sexual dimorphism in
brain responses to several neurological conditions. It is suggested that sex-related …
brain responses to several neurological conditions. It is suggested that sex-related …
Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects
Ö İş, Y Min, X Wang, SR Oatman, A Abraham Daniel… - Glia, 2025 - Wiley Online Library
Alzheimer's disease (AD) is the most common neurodegenerative dementia with multi‐
layered complexity in its molecular etiology. Multiple omics‐based approaches, such as …
layered complexity in its molecular etiology. Multiple omics‐based approaches, such as …
[HTML][HTML] Minding the gap: exploring neuroinflammatory and microglial sex differences in Alzheimer's disease
Research into Alzheimer's Disease (AD) describes a link between AD and the resident
immune cells of the brain, the microglia. Further, this suspected link is thought to have …
immune cells of the brain, the microglia. Further, this suspected link is thought to have …
A blood‐based multi‐pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups
Y Jiang, H Uhm, FC Ip, L Ouyang, RMN Lo… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Existing blood‐based biomarkers for Alzheimer's disease (AD) mainly
focus on its pathological features. However, studies on blood‐based biomarkers associated …
focus on its pathological features. However, studies on blood‐based biomarkers associated …