Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy

G Hajishengallis, T Chavakis… - Periodontology 2000, 2020 - Wiley Online Library
Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

Phage display derived monoclonal antibodies: from bench to bedside

MA Alfaleh, HO Alsaab, AB Mahmoud… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children

RA Porritt, A Binek, L Paschold, MN Rivas… - The Journal of clinical …, 2021 - jci.org
Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and
uncontrolled inflammatory response with multiorgan involvement, occurring weeks after …

The regulatory roles of neutrophils in adaptive immunity

Y Li, W Wang, F Yang, Y Xu, C Feng, Y Zhao - Cell Communication and …, 2019 - Springer
Neutrophils have long been considered as cells playing a crucial role in the immune
defence against invading pathogens. Accumulating evidence strongly supported the direct …

Neutrophil extracellular traps activate proinflammatory functions of human neutrophils

D Dömer, T Walther, S Möller, M Behnen… - Frontiers in …, 2021 - frontiersin.org
Neutrophil extracellular traps (NETs) consist of decondensed nuclear chromatin that is
associated with proteins and are released by neutrophils during an inflammatory response …

Neutrophil-derived cytokines: facts beyond expression

C Tecchio, A Micheletti, MA Cassatella - Frontiers in immunology, 2014 - frontiersin.org
Polymorphonuclear neutrophils, besides their involvement in primary defense against
infections–mainly through phagocytosis, generation of toxic molecules, release of enzymes …

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes

A Cerutti, M Cols, I Puga - Nature Reviews Immunology, 2013 - nature.com
Protective responses to microorganisms involve the nonspecific but rapid defence
mechanisms of the innate immune system, followed by the specific but slow defence …

Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

KC Navegantes, R de Souza Gomes… - Journal of translational …, 2017 - Springer
Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

A Mócsai - Journal of Experimental Medicine, 2013 - rupress.org
Neutrophils have long been considered simple suicide killers at the bottom of the hierarchy
of the immune response. That view began to change 10–20 yr ago, when the sophisticated …

[HTML][HTML] Neutrophil extracellular traps in inflammatory bowel disease: pathogenic mechanisms and clinical translation

B Drury, G Hardisty, RD Gray, G Ho - Cellular and molecular …, 2021 - Elsevier
Abstract The Inflammatory Bowel Diseases (IBD), Ulcerative Colitis (UC) and Crohn's
Disease (CD) are characterised by chronic non-resolving gut mucosal inflammation …