YAP/TAZ at the roots of cancer
F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
The biology of YAP/TAZ: hippo signaling and beyond
S Piccolo, S Dupont, M Cordenonsi - Physiological reviews, 2014 - journals.physiology.org
The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
R Cunningham, CG Hansen - Clinical Science, 2022 - portlandpress.com
Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …
signalling pathways. One such pathway that has garnered much attention in the field of …
YAP/TAZ signaling as a molecular link between fibrosis and cancer
S Noguchi, A Saito, T Nagase - International journal of molecular sciences, 2018 - mdpi.com
Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …
YAP and TAZ are not identical twins
F Reggiani, G Gobbi, A Ciarrocchi, V Sancisi - Trends in Biochemical …, 2021 - cell.com
Yes-associated protein (YAP) and TAZ (WW domain containing transcription regulator 1, or
WWTR1) are paralog transcriptional regulators, able to integrate mechanical, metabolic, and …
WWTR1) are paralog transcriptional regulators, able to integrate mechanical, metabolic, and …
The Hippo pathway in normal development and cancer
The Hippo pathway is a central regulator of organ size and tissue homeostasis. Hippo
kinases and adaptor proteins mediate the phosphorylation and inactivation of YAP and TAZ …
kinases and adaptor proteins mediate the phosphorylation and inactivation of YAP and TAZ …
Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ
Recent evidences suggest that stearoyl-CoA-desaturase 1 (SCD1), the enzyme involved in
monounsaturated fatty acids synthesis, has a role in several cancers. We previously …
monounsaturated fatty acids synthesis, has a role in several cancers. We previously …
A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy
M Shibata, K Ham, MO Hoque - International journal of cancer, 2018 - Wiley Online Library
YAP1 is one of the most important effectors of the Hippo pathway and has crosstalk with
other cancer promoting pathways. YAP1 contributes to cancer development in various ways …
other cancer promoting pathways. YAP1 contributes to cancer development in various ways …
A potential role of YAP/TAZ in the interplay between metastasis and metabolic alterations
H Yamaguchi, GM Taouk - Frontiers in oncology, 2020 - frontiersin.org
Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
are the downstream effectors of the Hippo signaling pathway that play a crucial role in …
are the downstream effectors of the Hippo signaling pathway that play a crucial role in …