The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …

An increasing number of patients worldwide suffers from chronic kidney disease (CKD).
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …

Serum creatinine concentration, the classical biomarker of chronic kidney disease (CKD) in
cats, has important limitations that decrease its value as a biomarker of early CKD. Recently …

Urologic diseases are commonly diagnosed health problems affecting people around the
world. More than 26 million people suffer from urologic diseases and the annual expenditure …

Background Accumulation of extracellular matrix in organs and tissues is a feature of both
aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis …

Trimethylamine N-oxide (TMAO), a product of gut microbiota metabolism, has previously
been shown to be implicated in chronic kidney disease. A high TMAO-containing diet has …

Highly abundant in mammals, collagens define the organization of tissues and participate in
cell signalling. Most of the 28 vertebrate collagens, with the exception of collagens VI, VII …

Natural extracellular matrices (ECM) are currently being studied as an alternative source for
organ transplantation or as new solutions to treat kidney injuries, which can evolve to end …

BACKGROUND Skeletal muscle maladaptation accompanies chronic kidney disease (CKD)
and negatively affects physical function. Emphasis in CKD has historically been placed on …

Introduction: In the AWARD-7 study in patients with type 2 diabetes and moderate-to-severe
chronic kidney disease, once-weekly dulaglutide slowed the decline in estimated glomerular …