Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Upon DNA damage or other stressors, the tumor suppressor p53 is activated, leading to
transient expression of the cyclin-dependent kinase inhibitor (CKI) p21. This either triggers …

Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …

In response to a variety of stresses, mammalian cells undergo a persistent proliferative
arrest known as cellular senescence. Many senescence‐inducing stressors are potentially …

The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …

p53 has been studied intensively as a major tumour suppressor that detects oncogenic
events in cancer cells and eliminates them through senescence (a permanent non …

Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …

The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint
effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could …

Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal
activation during embryonic development or normal adult life is linked with beneficial …

Sirtuin 7 (SIRT7) is a member of the mammalian family of nicotinamide adenine dinucleotide
(NAD+)-dependent histone/protein deacetylases, known as sirtuins. It acts as a potent …