Simple Summary Glioblastoma is the most common and aggressive malignant primary brain
cancer in adults. The prognosis remains poor following standard-of-care treatment with …

The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1)
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …

Glioblastoma (GBM) is the most common type of adult malignant brain tumor, but its
molecular mechanisms are not well understood. In addition, the knowledge of the disease …

Cancer cells rewire metabolism to favour the generation of specialized metabolites that
support tumour growth and reshape the tumour microenvironment,. Lysine functions as a …

Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular
functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is …

Sex differences in the incidence and outcome of human disease are broadly recognized but,
in most cases, not sufficiently understood to enable sex-specific approaches to treatment …

Despite extensive study, few therapeutic targets have been identified for glioblastoma
(GBM). Here we show that patient-derived glioma sphere cultures (GSCs) that resemble …

CD47, a “don't eat me” signal for phagocytic cells, is expressed on the surface of all human
solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue …

Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with
mitogen-activated protein kinase (MAPK) pathway alterations. Surgically inaccessible …

We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …