The neutral lipids diacylglycerols (DAGs) are involved in a plethora of metabolic pathways.
They function as components of cellular membranes, as building blocks for glycero …

The management of visceral pain in patients with disorders of gut–brain interaction, notably
irritable bowel syndrome, presents a considerable clinical challenge, with few available …

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-
arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of …

The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal
barrier function and immune regulation are key determinants of intestinal homeostasis and …

Monoglyerides (MGs) are short-lived, intermediary lipids deriving from the degradation of
phospho-and neutral lipids, and monoglyceride lipase (MGL), also designated as …

Background In ancient medicine, extracts of the marijuana plant Cannabis sativa were used
against diseases of the gastrointestinal (GI) tract. Today, our knowledge of the ingredients of …

The endocannabinoid system, with its receptors and ligands, is present in the gut epithelium
and enteroendocrine cells, and is able to modulate brain functions, both indirectly through …

The endocannabinoid system is involved in a wide range of processes including the control
of energy acquisition and expenditure. Endocannabinoids and their receptors are present in …

Endocannabinoids are host-derived lipid hormones that fundamentally impact
gastrointestinal (GI) biology. The use of cannabis and other exocannabinoids as anecdotal …

Cannabis sativa and its extracts have been used for centuries, both medicinally and
recreationally. There is accumulating evidence that exogenous cannabis and related …