[HTML][HTML] Emerging microglia biology defines novel therapeutic approaches for Alzheimer's disease
Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow
cognitive decline have not yet been successful. Many of these approaches have targeted the …
cognitive decline have not yet been successful. Many of these approaches have targeted the …
The role of calcium–calcineurin–NFAT signaling pathway in health and autoimmune diseases
Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …
functions. In the immune system, calcium signals play a central role in a variety of cellular …
Calcium signalling in lymphocyte activation and disease
S Feske - Nature Reviews Immunology, 2007 - nature.com
Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of …
differentiation, gene transcription and effector functions. An increase in intracellular levels of …
Bruton's tyrosine kinase (BTK) inhibitors and autoimmune diseases: making sense of BTK inhibitor specificity profiles and recent clinical trial successes and failures
GE Ringheim, M Wampole, K Oberoi - Frontiers in immunology, 2021 - frontiersin.org
Clinical development of BTK kinase inhibitors for treating autoimmune diseases has lagged
behind development of these drugs for treating cancers, due in part from concerns over the …
behind development of these drugs for treating cancers, due in part from concerns over the …
Protein kinase D at the Golgi controls NLRP3 inflammasome activation
The inflammasomes are multiprotein complexes sensing tissue damage and infectious
agents to initiate innate immune responses. Different inflammasomes containing distinct …
agents to initiate innate immune responses. Different inflammasomes containing distinct …
[HTML][HTML] Cold Urticaria, Immunodeficiency, and Autoimmunity Related to PLCG2 Deletions
MJ Ombrello, EF Remmers, G Sun… - … England Journal of …, 2012 - Mass Medical Soc
Background Mendelian analysis of disorders of immune regulation can provide insight into
molecular pathways associated with host defense and immune tolerance. Methods We …
molecular pathways associated with host defense and immune tolerance. Methods We …
Protective genes and pathways in Alzheimer's disease: moving towards precision interventions
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
Multiple roles of phosphoinositide-specific phospholipase C isozymes
PG Suh, JI Park, L Manzoli, L Cocco, JC Peak… - BMB …, 2008 - koreascience.kr
Phosphoinositide-specific phospholipase C is an effector molecule in the signal transduction
process. It generates two second messengers, inositol-1, 4, 5-trisphosphate and …
process. It generates two second messengers, inositol-1, 4, 5-trisphosphate and …
A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency
Whole-exome sequencing was performed in a family affected by dominantly inherited
inflammatory disease characterized by recurrent blistering skin lesions, bronchiolitis …
inflammatory disease characterized by recurrent blistering skin lesions, bronchiolitis …
Phosphoinositide signalling in cancer: beyond PI3K and PTEN
TD Bunney, M Katan - Nature Reviews Cancer, 2010 - nature.com
There are numerous studies that suggest multiple links between the cellular
phosphoinositide system and cancer. As key roles in cancer have been established for PI3K …
phosphoinositide system and cancer. As key roles in cancer have been established for PI3K …