The unabated progress in next-generation sequencing technologies is fostering a wave of
new genomics, epigenomics, transcriptomics and proteomics technologies. These …

Fiji is a distribution of the popular open-source software ImageJ focused on biological-image
analysis. Fiji uses modern software engineering practices to combine powerful software …

It is not known at present whether neuronal cell-type diversity—defined by cell-type-specific
anatomical, biophysical, functional and molecular signatures—can be reduced to relatively …

The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

The comprehensive reconstruction of cell lineages in complex multicellular organisms is a
central goal of developmental biology. We present an open-source computational …

Recording light-microscopy images of large, nontransparent specimens, such as develo**
multicellular organisms, is complicated by decreased contrast resulting from light scattering …

We present a combined report on the results of three editions of the Cell Tracking
Challenge, an ongoing initiative aimed at promoting the development and objective …

Optical imaging of the dynamics of living specimens involves tradeoffs between spatial
resolution, temporal resolution, and phototoxicity, made more difficult in three dimensions …

The C. elegans genome has been completely sequenced, and the developmental anatomy
of this model organism is described at single-cell resolution. Here we utilize strategies that …

Quantitative information on growing organs is required to better understand morphogenesis
in both plants and animals. However, detailed analyses of growth patterns at cellular …