Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized
by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking …

Fanconi anaemia (FA) has recently become an attractive model to study breast cancer
susceptibility (BRCA) genes, as three FA genes, FANCD1, FANCN and FANCJ, are identical …

Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder
characterized by cellular sensitivity to mitomycin C and ionizing radiation. Although six FA …

Ovarian tumor cells are often genomically unstable and hypersensitive to cisplatin. To
understand the molecular basis for this phenotype, we examined the integrity of the Fanconi …

Fanconi anemia is a recessively inherited disease characterized by congenital defects, bone
marrow failure and cancer susceptibility,. Cells from individuals with Fanconi anemia are …

DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce
mutations, chromosomal rearrangements and cell death. Inducers of ICLs are important …

The past few years have witnessed a considerable expansion in our understanding of the
pathways that maintain chromosome stability in dividing cells through the identification of …

Fanconi anemia (FA) and ataxia telangiectasia (AT) are clinically distinct autosomal
recessive disorders characterized by spontaneous chromosome breakage and …

Fanconi anaemia (FA) is an autosomal recessive disease characterised by congenital
abnormalities, defective haemopoiesis, and a high risk of develo** acute myeloid …

We review the genes and proteins related to the homologous recombinational repair (HRR)
pathway that are implicated in cancer through either genetic disorders that predispose to …