Biological nanopore approach for single‐molecule protein sequencing
Proteins are responsible for the occurrence and treatment of many diseases, and therefore
protein sequencing will revolutionize proteomics and clinical diagnostics. Biological …
protein sequencing will revolutionize proteomics and clinical diagnostics. Biological …
The application of single molecule nanopore sensing for quantitative analysis
Nanopore-based sensors typically work by monitoring transient pulses in conductance via
current–time traces as molecules translocate through the nanopore. The unique property of …
current–time traces as molecules translocate through the nanopore. The unique property of …
Peptide sequencing based on host–guest interaction-assisted nanopore sensing
Direct protein sequencing technologies with improved sensitivity and throughput are still
needed. Here, we propose an alternative method for peptide sequencing based on …
needed. Here, we propose an alternative method for peptide sequencing based on …
Nanopore-based protein identification
The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome
identification would greatly benefit cell biology research and clinical medicine. Proteins are …
identification would greatly benefit cell biology research and clinical medicine. Proteins are …
Single Molecule Ratcheting Motion of Peptides in a Mycobacterium smegmatis Porin A (MspA) Nanopore
S Yan, J Zhang, Y Wang, W Guo, S Zhang, Y Liu… - Nano …, 2021 - ACS Publications
Diverse functions of proteins, including synthesis, catalysis, and signaling, result from their
highly variable amino acid sequences. The technology allowing for direct analysis of protein …
highly variable amino acid sequences. The technology allowing for direct analysis of protein …
FraC nanopores with adjustable diameter identify the mass of opposite-charge peptides with 44 dalton resolution
A high throughput single-molecule method for identifying peptides and sequencing proteins
based on nanopores could reduce costs and increase speeds of sequencing, allow the …
based on nanopores could reduce costs and increase speeds of sequencing, allow the …
Nanopore detection of metal ions: Current status and future directions
GM Roozbahani, X Chen, Y Zhang, L Wang… - Small …, 2020 - Wiley Online Library
In this review, recent research efforts that aimed at develo** nanopore sensors for
detection of metal ions, which play a crucial role in environmental safety and human health …
detection of metal ions, which play a crucial role in environmental safety and human health …
Biological nanopores: Engineering on demand
Nanopore-based sensing is a powerful technique for the detection of diverse organic and
inorganic molecules, long-read sequencing of nucleic acids, and single-molecule analyses …
inorganic molecules, long-read sequencing of nucleic acids, and single-molecule analyses …
Enhanced identification of Tau acetylation and phosphorylation with an engineered aerolysin nanopore
Posttranslational modifications (PTMs) affect protein function/dysfunction, playing important
roles in the occurrence and development of tauopathies including Alzheimer's disease. PTM …
roles in the occurrence and development of tauopathies including Alzheimer's disease. PTM …
Detection of peptides with different charges and lengths by using the aerolysin nanopore
The aerolysin nanopore has a high sensitivity for molecular sensing, owing to its super‐
narrow diameter and highly charged lumen structure. Here, taking advantages of its high …
narrow diameter and highly charged lumen structure. Here, taking advantages of its high …