Frontotemporal lobar degeneration

M Grossman, WW Seeley, AL Boxer, AE Hillis… - Nature Reviews …, 2023‏ - nature.com
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

Clinical assessment of social cognitive function in neurological disorders

JD Henry, W Von Hippel, P Molenberghs… - Nature Reviews …, 2016‏ - nature.com
Social cognition broadly refers to the processing of social information in the brain that
underlies abilities such as the detection of others' emotions and responding appropriately to …

Frontotemporal dementia: latest evidence and clinical implications

JJ Young, M Lavakumar, D Tampi… - Therapeutic …, 2018‏ - journals.sagepub.com
Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive
syndromes that present with impairment of executive functioning, changes in behavior, and …

Clinical practice with anti-dementia drugs: a revised (third) consensus statement from the British Association for Psychopharmacology

JT O'Brien, C Holmes, M Jones… - Journal of …, 2017‏ - journals.sagepub.com
The British Association for Psychopharmacology coordinated a meeting of experts to review
and revise its previous 2011 guidelines for clinical practice with anti-dementia drugs. As …

Development of disease-modifying drugs for frontotemporal dementia spectrum disorders

F Panza, M Lozupone, D Seripa, A Daniele… - Nature Reviews …, 2020‏ - nature.com
Frontotemporal dementia (FTD) encompasses a spectrum of clinical syndromes
characterized by progressive executive, behavioural and language dysfunction. The various …

Therapy and clinical trials in frontotemporal dementia: past, present, and future

RM Tsai, AL Boxer - Journal of neurochemistry, 2016‏ - Wiley Online Library
Frontotemporal dementia (FTD) is a common form of dementia with heterogeneous clinical
presentations and distinct clinical syndromes. This article will review currently available …

Social inappropriateness in neurodegenerative disorders

P Desmarais, KL Lanctôt, M Masellis… - International …, 2018‏ - cambridge.org
Background: New onset of mood and behavioral changes in middle-aged patients are
frequently the first manifestations of an unrecognized neurocognitive disorder. Impairment of …

Peri-infarct upregulation of the oxytocin receptor in vascular dementia

EC McKay, JS Beck, SK Khoo… - … of Neuropathology & …, 2019‏ - academic.oup.com
Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet
there are few therapeutic options to protect cognitive function following cerebrovascular …

The role of GPCRs in neurodegenerative diseases: avenues for therapeutic intervention

Y Huang, N Todd, A Thathiah - Current opinion in pharmacology, 2017‏ - Elsevier
Highlights•GPCRs are implicated in the pathophysiology of various neurodegenerative
diseases.•Currently available therapies do not cure the discussed neurodegenerative …

Oxytocin release increases with age and is associated with life satisfaction and prosocial behaviors

PJ Zak, B Curry, T Owen, JA Barraza - Frontiers in behavioral …, 2022‏ - frontiersin.org
Hel** behaviors and life satisfaction generally increase after middle-age. Identifying the
neural substrates of prosocial behaviors in older adults may offer additional insights into …