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Heterogeneity in tuberculosis
Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …
in a range of clinical presentations in humans. Most infections manifest as a clinically …
Animal and translational models of SARS-CoV-2 infection and COVID-19
COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …
community is in a race to define and develop effective preventions and treatments. The …
Zika virus: new clinical syndromes and its emergence in the western hemisphere
Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of
outbreaks accompanied by unexpectedly severe clinical complications brought this virus …
outbreaks accompanied by unexpectedly severe clinical complications brought this virus …
The diversity outbred mouse population
Abstract The Diversity Outbred (DO) population is a heterogeneous stock derived from the
same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically …
same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically …
MAGIC populations in crops: current status and future prospects
Key message MAGIC populations present novel challenges and opportunities in crops due
to their complex pedigree structure. They offer great potential both for dissecting genomic …
to their complex pedigree structure. They offer great potential both for dissecting genomic …
Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling
Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high
ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that …
ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that …
High-resolution genetic map** using the Mouse Diversity outbred population
Abstract The JAX Diversity Outbred population is a new mouse resource derived from
partially inbred Collaborative Cross strains and maintained by randomized outcrossing. As …
partially inbred Collaborative Cross strains and maintained by randomized outcrossing. As …
[HTML][HTML] Reproducibility and replicability of rodent phenoty** in preclinical studies
The scientific community is increasingly concerned with the proportion of published
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …
Genomes of the mouse collaborative cross
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
Strategies for containing Ebola in west Africa
The ongoing Ebola outbreak poses an alarming risk to the countries of West Africa and
beyond. To assess the effectiveness of containment strategies, we developed a stochastic …
beyond. To assess the effectiveness of containment strategies, we developed a stochastic …