Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches

CM Manyelo, RS Solomons, G Walzl… - Journal of clinical …, 2021 - journals.asm.org
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing
high mortality or disability. Clinical management of the disease is challenging due to …

Recent advances in understanding the human host immune response in tuberculous meningitis

JR Barnacle, AG Davis, RJ Wilkinson - Frontiers in Immunology, 2024 - frontiersin.org
Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in
approximately 25% cases despite antibiotic therapy, and half of survivors are left with …

Central nervous system tuberculosis

S Dian, AR Ganiem… - Current opinion in …, 2021 - journals.lww.com
Recent studies in the field of CNS-TB have largely focussed on TB meningitis. The outcome
may improve by optimizing treatment dosing. This needs to be confirmed in clinical trials …

Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection

X Zhang, Z Zhao, Q Wu, L Wang, L Li, M Wang, Y Ren… - Cell Reports, 2023 - cell.com
Tuberculous meningitis (TBM) is the most severe and deadly manifestation of tuberculosis.
Neurological complications are observed in up to 50% of patients affected. Here, attenuated …

[HTML][HTML] CNS tuberculosis

M Gupta, EH Tobin, S Munakomi - StatPearls [Internet], 2024 - ncbi.nlm.nih.gov
CNS Tuberculosis - StatPearls - NCBI Bookshelf US flag An official website of the United States
government Here's how you know NIH NLM Logo Access keys NCBI Homepage MyNCBI …

Recent developments in tuberculous meningitis pathogenesis and diagnostics

FV Cresswell, AG Davis, K Sharma… - Wellcome open …, 2021 - pmc.ncbi.nlm.nih.gov
The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary
molecular biology technologies have allowed for recent improvements in our understanding …

The use of thalidomide to treat children with tuberculosis meningitis: a review

R Van Toorn, SD Zaharie, JA Seddon, M van der Kuip… - Tuberculosis, 2021 - Elsevier
Much of the morbidity and mortality caused by tuberculous meningitis (TBM) is mediated by
a dysregulated immune response. Effective host-directed therapy is therefore critical to …

Single-cell transcriptome reveals highly complement activated microglia cells in association with pediatric tuberculous meningitis

S Mo, C Shi, Y Cai, M Xu, H Xu, Y Xu, K Zhang… - Frontiers in …, 2024 - frontiersin.org
Background Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB)
causing high mortality and disability. TBM arises due to immune dysregulation, but the …

The changes and its significance of peripheral blood NK cells in patients with tuberculous meningitis

J Mi, Y Liu, Y Xue, W Sun, Y Liang, J Liang… - Frontiers in …, 2024 - frontiersin.org
Objective Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB). The
purpose of this study was to explore the relationship between the number of natural killer …

Thalidomide and phosphodiesterase 4 inhibitors as host directed therapeutics for tuberculous meningitis: insights from the rabbit model

R Kumar, A Kolloli, P Singh, C Vinnard… - Frontiers in Cellular …, 2020 - frontiersin.org
Tuberculous meningitis (TBM) is the most devastating form of extrapulmonary
Mycobacterium tuberculosis infection in humans. Severe inflammation and extensive tissue …