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Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing
high mortality or disability. Clinical management of the disease is challenging due to …
high mortality or disability. Clinical management of the disease is challenging due to …
Recent advances in understanding the human host immune response in tuberculous meningitis
Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in
approximately 25% cases despite antibiotic therapy, and half of survivors are left with …
approximately 25% cases despite antibiotic therapy, and half of survivors are left with …
Central nervous system tuberculosis
Recent studies in the field of CNS-TB have largely focussed on TB meningitis. The outcome
may improve by optimizing treatment dosing. This needs to be confirmed in clinical trials …
may improve by optimizing treatment dosing. This needs to be confirmed in clinical trials …
Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection
X Zhang, Z Zhao, Q Wu, L Wang, L Li, M Wang, Y Ren… - Cell Reports, 2023 - cell.com
Tuberculous meningitis (TBM) is the most severe and deadly manifestation of tuberculosis.
Neurological complications are observed in up to 50% of patients affected. Here, attenuated …
Neurological complications are observed in up to 50% of patients affected. Here, attenuated …
[HTML][HTML] CNS tuberculosis
M Gupta, EH Tobin, S Munakomi - StatPearls [Internet], 2024 - ncbi.nlm.nih.gov
CNS Tuberculosis - StatPearls - NCBI Bookshelf US flag An official website of the United States
government Here's how you know NIH NLM Logo Access keys NCBI Homepage MyNCBI …
government Here's how you know NIH NLM Logo Access keys NCBI Homepage MyNCBI …
Recent developments in tuberculous meningitis pathogenesis and diagnostics
The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary
molecular biology technologies have allowed for recent improvements in our understanding …
molecular biology technologies have allowed for recent improvements in our understanding …
The use of thalidomide to treat children with tuberculosis meningitis: a review
R Van Toorn, SD Zaharie, JA Seddon, M van der Kuip… - Tuberculosis, 2021 - Elsevier
Much of the morbidity and mortality caused by tuberculous meningitis (TBM) is mediated by
a dysregulated immune response. Effective host-directed therapy is therefore critical to …
a dysregulated immune response. Effective host-directed therapy is therefore critical to …
Single-cell transcriptome reveals highly complement activated microglia cells in association with pediatric tuberculous meningitis
Background Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB)
causing high mortality and disability. TBM arises due to immune dysregulation, but the …
causing high mortality and disability. TBM arises due to immune dysregulation, but the …
The changes and its significance of peripheral blood NK cells in patients with tuberculous meningitis
J Mi, Y Liu, Y Xue, W Sun, Y Liang, J Liang… - Frontiers in …, 2024 - frontiersin.org
Objective Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB). The
purpose of this study was to explore the relationship between the number of natural killer …
purpose of this study was to explore the relationship between the number of natural killer …
Thalidomide and phosphodiesterase 4 inhibitors as host directed therapeutics for tuberculous meningitis: insights from the rabbit model
Tuberculous meningitis (TBM) is the most devastating form of extrapulmonary
Mycobacterium tuberculosis infection in humans. Severe inflammation and extensive tissue …
Mycobacterium tuberculosis infection in humans. Severe inflammation and extensive tissue …